Reversible nitrous oxide-induced myeloneuropathy with pernicious anemia: Case report and literature review

Mike A. Singer; Christos Lazaridis; Sharon P. Nations; Gil I. Wolfe

doi:10.1002/mus.20840

Reversible nitrous oxide-induced myeloneuropathy with pernicious anemia: Case report and literature review

Mike A. Singer, Christos Lazaridis, Sharon P. Nations, Gil I. Wolfe

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

A previously healthy 27-year-old woman developed a sub-acute myeloneuropathy after receiving nitrous oxide anesthesia for dental procedures. Neurologic evaluation revealed that she was vitamin B₁₂ deficient due to underlying pernicious anemia. Discontinuation of nitrous oxide and supplementation with vitamin B₁₂ resulted in dramatic clinical improvement, with near-complete normalization of her neurologic examination. This case and published reports reviewed here emphasize that favorable outcomes are possible following prompt recognition and treatment of vitamin B ₁₂ deficiency.

Original language	English (US)
Pages (from-to)	125-129
Number of pages	5
Journal	Muscle and Nerve
Volume	37
Issue number	1
DOIs	https://doi.org/10.1002/mus.20840
State	Published - Jan 1 2008

Keywords

Cobalamin
Deficiency
Nitrous oxide
Pernicious anemia
Vitamin B

ASJC Scopus subject areas

Physiology
Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)

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10.1002/mus.20840

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abstract = "A previously healthy 27-year-old woman developed a sub-acute myeloneuropathy after receiving nitrous oxide anesthesia for dental procedures. Neurologic evaluation revealed that she was vitamin B12 deficient due to underlying pernicious anemia. Discontinuation of nitrous oxide and supplementation with vitamin B12 resulted in dramatic clinical improvement, with near-complete normalization of her neurologic examination. This case and published reports reviewed here emphasize that favorable outcomes are possible following prompt recognition and treatment of vitamin B 12 deficiency.",

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AB - A previously healthy 27-year-old woman developed a sub-acute myeloneuropathy after receiving nitrous oxide anesthesia for dental procedures. Neurologic evaluation revealed that she was vitamin B12 deficient due to underlying pernicious anemia. Discontinuation of nitrous oxide and supplementation with vitamin B12 resulted in dramatic clinical improvement, with near-complete normalization of her neurologic examination. This case and published reports reviewed here emphasize that favorable outcomes are possible following prompt recognition and treatment of vitamin B 12 deficiency.

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KW - Deficiency

KW - Nitrous oxide

KW - Pernicious anemia

KW - Vitamin B

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Reversible nitrous oxide-induced myeloneuropathy with pernicious anemia: Case report and literature review

Abstract

Keywords

ASJC Scopus subject areas

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