Reverse redistribution of thallium-201 detected by SPECT imaging after dipyridamole in angina pectoris

Jeffrey J. Popma, Thomas C. Smitherman, Brandy S. Walker, Theodore R. Simon, Gregory J. Dehmer

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Reverse redistribution refers to a thallium-201 perfusion defect that develops or becomes more evident on delayed imaging compared with the initial image immediately after stress. To determine the diagnostic importance of reverse redistribution after intravenous dipyridamole, thallium-201 single photon emission computed tomography and quantitative coronary arteriography were performed in 90 men with angina pectoris. Of the 250 myocardial segments analyzed, reverse redistribution was present in 17 (7%). Minimal coronary cross-sectional area in proximal vessel segments was ≤2.0 mm2 more often in regions with transient perfusion abnormalities than in regions with reverse redistribution (66 vs 29%, p < 0.05). Compared with regions exhibiting transient perfusion abnormalities, regions with reverse redistribution had larger proximal arterial diameters (1.9 ± 1.1 vs 1.3 ± 1.1 mm, p < 0.001) and cross-sectional areas (3.9 ±3.1 vs 2.2 ± 2.6 mm2, p < 0.001). Coronary artery dimensions and relative stenosis severity did not differ between those regions with normal perfusion and those with reverse redistribution. Reverse redistribution detected by thallium-201 single photon emission computed tomographic imaging after dipyridamole is uncommon, appears to occur as frequently in normal subjects as in patients undergoing coronary arteriography and does not indicate the presence of severe coronary artery disease.

Original languageEnglish (US)
Pages (from-to)1176-1180
Number of pages5
JournalThe American journal of cardiology
Issue number18
StatePublished - May 15 1990

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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