Retinoblastoma Tumorigenesis

Michael A. Dyer, Michael A. Dyer, J. William Harbour, J. William Harbour, J. William Harbour

Research output: Chapter in Book/Report/Conference proceedingChapter


Tumorigenesis is a multistep process that involves sequential genetic alterations [1]. Preneoplastic cells must overcome their dependence on extrinsic mitogenic signals, evade apoptosis, prevent degradation of life-span-limiting telomeres, recruit vasculature, and acquire invasive properties to become malignant tumor cells [1].

Original languageEnglish (US)
Title of host publicationClinical Ophthalmic Oncology
Subtitle of host publicationRetinoblastoma, Second Edition
PublisherSpringer Berlin Heidelberg
Number of pages8
ISBN (Electronic)9783662434512
ISBN (Print)9783662434505
StatePublished - Jan 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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