TY - JOUR
T1 - Resting-state anticorrelations between medial and lateral prefrontal cortex
T2 - Association with working memory, aging, and individual differences
AU - Keller, Joseph B.
AU - Hedden, Trey
AU - Thompson, Todd W.
AU - Anteraper, Sheeba A.
AU - Gabrieli, John D.E.
AU - Whitfield-Gabrieli, Susan
N1 - Publisher Copyright:
© 2014 Elsevier Ltd.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - We examined how variation in working memory (WM) capacity due to aging or individual differences among young adults is associated with intrinsic or resting-state anticorrelations, particularly between (1) the medial prefrontal cortex (MPFC), a component of the default-mode network (DMN) that typically decreases in activation during external, attention-demanding tasks, and (2) the dorsolateral prefrontal cortex (DLPFC), a component of the fronto-parietal control network that supports executive functions and WM and typically increases in activation during attention-demanding tasks. We compared the magnitudes of MPFC-DLPFC anticorrelations between healthy younger and older participants (Experiment 1) and related the magnitudes of these anticorrelations to individual differences on two behavioral measures of WM capacity in two independent groups of young adults (Experiments 1 and 2). Relative to younger adults, older adults exhibited reductions in WM capacity and in MPFC-DLPFC anticorrelations. Within younger adults, greater MPFC-DLPFC anticorrelation at rest correlated with greater WM capacity. These findings show that variation in MPFC-DLPFC anticorrelations, whether related to aging or to individual differences, may reflect an intrinsic functional brain architecture supportive of WM capacity.
AB - We examined how variation in working memory (WM) capacity due to aging or individual differences among young adults is associated with intrinsic or resting-state anticorrelations, particularly between (1) the medial prefrontal cortex (MPFC), a component of the default-mode network (DMN) that typically decreases in activation during external, attention-demanding tasks, and (2) the dorsolateral prefrontal cortex (DLPFC), a component of the fronto-parietal control network that supports executive functions and WM and typically increases in activation during attention-demanding tasks. We compared the magnitudes of MPFC-DLPFC anticorrelations between healthy younger and older participants (Experiment 1) and related the magnitudes of these anticorrelations to individual differences on two behavioral measures of WM capacity in two independent groups of young adults (Experiments 1 and 2). Relative to younger adults, older adults exhibited reductions in WM capacity and in MPFC-DLPFC anticorrelations. Within younger adults, greater MPFC-DLPFC anticorrelation at rest correlated with greater WM capacity. These findings show that variation in MPFC-DLPFC anticorrelations, whether related to aging or to individual differences, may reflect an intrinsic functional brain architecture supportive of WM capacity.
KW - Aging
KW - Default mode network
KW - Functional connectivity
KW - Resting-state fMRI
KW - Working memory
UR - http://www.scopus.com/inward/record.url?scp=84920110721&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84920110721&partnerID=8YFLogxK
U2 - 10.1016/j.cortex.2014.12.001
DO - 10.1016/j.cortex.2014.12.001
M3 - Article
C2 - 25562175
AN - SCOPUS:84920110721
SN - 0010-9452
VL - 64
SP - 271
EP - 280
JO - Cortex
JF - Cortex
ER -