Response of the Thymus and Immunologically Induced Lymphopenia

A. M. Denman; E. P. Frenkel; M. Ziff

doi:10.3181/00379727-125-32294

Response of the Thymus and Immunologically Induced Lymphopenia

A. M. Denman, E. P. Frenkel, M. Ziff

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Administration of specific rabbit anti-rat lymphocyte gamma globulin (IgG) produced prolonged severe lymphopenia in rats made tolerant to normal rabbit IgG. A decrease in thymic weight due to loss of small lymphocytes occurred. Combined morphologic and biochemical studies demonstrated marked proliferative activity of the precursor cells. The anti-lymphocyte IgG did not appear to gain entrance into the thymus.

Original language	English (US)
Pages (from-to)	1127-1130
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	125
Issue number	4
DOIs	https://doi.org/10.3181/00379727-125-32294
State	Published - Sep 8 1967

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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title = "Response of the Thymus and Immunologically Induced Lymphopenia",

abstract = "Administration of specific rabbit anti-rat lymphocyte gamma globulin (IgG) produced prolonged severe lymphopenia in rats made tolerant to normal rabbit IgG. A decrease in thymic weight due to loss of small lymphocytes occurred. Combined morphologic and biochemical studies demonstrated marked proliferative activity of the precursor cells. The anti-lymphocyte IgG did not appear to gain entrance into the thymus.",

author = "Denman, {A. M.} and Frenkel, {E. P.} and M. Ziff",

note = "Funding Information: Supported by USPHS grants 2A-5154 and AM-02071, Nat. Inst. of Arthritis & Metab. Dis. and CA 06853 from Nat. Cancer Inst. ",

year = "1967",

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doi = "10.3181/00379727-125-32294",

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T1 - Response of the Thymus and Immunologically Induced Lymphopenia

AU - Denman, A. M.

AU - Frenkel, E. P.

AU - Ziff, M.

N1 - Funding Information: Supported by USPHS grants 2A-5154 and AM-02071, Nat. Inst. of Arthritis & Metab. Dis. and CA 06853 from Nat. Cancer Inst.

PY - 1967/9/8

Y1 - 1967/9/8

N2 - Administration of specific rabbit anti-rat lymphocyte gamma globulin (IgG) produced prolonged severe lymphopenia in rats made tolerant to normal rabbit IgG. A decrease in thymic weight due to loss of small lymphocytes occurred. Combined morphologic and biochemical studies demonstrated marked proliferative activity of the precursor cells. The anti-lymphocyte IgG did not appear to gain entrance into the thymus.

AB - Administration of specific rabbit anti-rat lymphocyte gamma globulin (IgG) produced prolonged severe lymphopenia in rats made tolerant to normal rabbit IgG. A decrease in thymic weight due to loss of small lymphocytes occurred. Combined morphologic and biochemical studies demonstrated marked proliferative activity of the precursor cells. The anti-lymphocyte IgG did not appear to gain entrance into the thymus.

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JO - Proceedings of the Society for Experimental Biology and Medicine

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Response of the Thymus and Immunologically Induced Lymphopenia

Abstract

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