Repair of Nitrous Acid Damage to DNA in Escherichia coli

Ricardo Da Roza, Errol C. Friedberg, Bruce K. Duncan, Huber R. Warner

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


A number of mutant strains of Escherichia coli have been examined for their sensitivity to nitrous acid and in some instances to methylmethanesulfonate. All ung mutants tested are abnormally sensitive to nitrous acid. Since the ung mutation is phenotypically expressed as a defect in uracil DNA glycosidase, this observation supports the contention that treatment of cells with nitrous acid causes deamination of cytosine to uracil. In addition the observed sentitivity indicates that the ung gene is involved in the repair of uracil in DNA. Studies with other mutants suggest that both exonuclease III and DNA polymerase I of E. coli are involved in the repair of nitrous acid damage in vivo.

Original languageEnglish (US)
Pages (from-to)4934-4939
Number of pages6
Issue number22
StatePublished - Nov 1 1977

ASJC Scopus subject areas

  • Biochemistry


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