TY - JOUR
T1 - Renal vasoconstriction by the endothelial cell-derived peptide endothelin in spontaneously hypertensive rats
AU - Hirata, Y.
AU - Matsuoka, H.
AU - Kimura, K.
AU - Fukui, K.
AU - Hayakawa, H.
AU - Suzuki, E.
AU - Sugimoto, T.
AU - Sugimoto, T.
AU - Yanagisawa, Masashi
AU - Masaki, T.
PY - 1989
Y1 - 1989
N2 - The effects of endothelin on systemic and renal hemodynamics in anesthetized spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats were examined. Endothelin (500 ng i.v.+1,000 ng/hr per 300-g rat) elevated mean blood pressure by 13% (p<0.02) and decreased renal blood flow by 71% and glomerular filtration rate by 66% (both p<0.01), resulting in a 430% (p<0.05) increase in renal vascular resistance (RVR) in SHR. This rise in blood pressure was associated with a significant increase in hematocrit (+8%), but a decrease in urinary sodium excretion (-51%). This dose of endothelin reduced cardiac output by 40% (p<0.001) and brought about a 96% (p>0.01) rise in systemic vascular resistance (SVR). However, the SVR increase was significantly smaller than the RVR increase. These changes in systemic and renal hemodynamics were observed in a dose-dependent manner, and the degrees of change did not differ between the two strains. Additional infusion of atrial natriuretic peptide (0.33 μg/kg/min) into SHR completely reversed the changes in blood pressure and renal hemodynamics caused by endothelin, resulting in pronounced natriuresis (+760%). The renal vascular casting study revealed that endothelin mainly constricted the arcuate and interlobular arteries, as well as afferent arterioles. These results suggest that endothelin may be involved in blood pressure and body fluid volume regulation through systemic and renal vasoconstriction.
AB - The effects of endothelin on systemic and renal hemodynamics in anesthetized spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats were examined. Endothelin (500 ng i.v.+1,000 ng/hr per 300-g rat) elevated mean blood pressure by 13% (p<0.02) and decreased renal blood flow by 71% and glomerular filtration rate by 66% (both p<0.01), resulting in a 430% (p<0.05) increase in renal vascular resistance (RVR) in SHR. This rise in blood pressure was associated with a significant increase in hematocrit (+8%), but a decrease in urinary sodium excretion (-51%). This dose of endothelin reduced cardiac output by 40% (p<0.001) and brought about a 96% (p>0.01) rise in systemic vascular resistance (SVR). However, the SVR increase was significantly smaller than the RVR increase. These changes in systemic and renal hemodynamics were observed in a dose-dependent manner, and the degrees of change did not differ between the two strains. Additional infusion of atrial natriuretic peptide (0.33 μg/kg/min) into SHR completely reversed the changes in blood pressure and renal hemodynamics caused by endothelin, resulting in pronounced natriuresis (+760%). The renal vascular casting study revealed that endothelin mainly constricted the arcuate and interlobular arteries, as well as afferent arterioles. These results suggest that endothelin may be involved in blood pressure and body fluid volume regulation through systemic and renal vasoconstriction.
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U2 - 10.1161/01.RES.65.5.1370
DO - 10.1161/01.RES.65.5.1370
M3 - Article
C2 - 2680150
AN - SCOPUS:0024444523
SN - 0009-7330
VL - 65
SP - 1370
EP - 1379
JO - Circulation research
JF - Circulation research
IS - 5
ER -