Renal senescence in 2008: Progress and challenges

Xin J. Zhou, Ramesh Saxena, Zhihong Liu, N. D. Vaziri, Fred G. Silva

Research output: Contribution to journalReview articlepeer-review

72 Scopus citations


Kidneys are significantly affected by profound anatomic and functional changes with senescence. These changes lead to decline in glomerular filtration rate, decreased urinary concentrating and diluting ability, diminished urinary acidification, and impaired potassium clearance, to list a few. Such changes make the elderly prone to drug toxicity and serious fluid and electrolyte imbalance. While the entire mystery of aging is far from being clear, the role of oxidative stress, telomere length, Klotho gene expression, and the renin angiotensin system seem to be the key mechanisms involved in aging. Aging, being a complex process, involves an array of intertwined molecular pathways. Simultaneous study of multiple molecular pathways in parallel could provide invaluable information in understanding the clinical course of kidney aging and elucidating mechanisms that play key roles in the aging process. A better understanding of these mechanisms may help to preserve renal function, improve morbidity and mortality, and hopefully reduce healthcare costs for the aging population.

Original languageEnglish (US)
Pages (from-to)823-839
Number of pages17
JournalInternational Urology and Nephrology
Issue number3
StatePublished - Sep 2008


  • Aging
  • Geriatric nephrology
  • Klotho
  • Oxidative stress
  • Renal pathology
  • Senescence
  • Telomeres

ASJC Scopus subject areas

  • Nephrology
  • Urology


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