TY - JOUR
T1 - Renal senescence in 2008
T2 - Progress and challenges
AU - Zhou, Xin J.
AU - Saxena, Ramesh
AU - Liu, Zhihong
AU - Vaziri, N. D.
AU - Silva, Fred G.
PY - 2008/9
Y1 - 2008/9
N2 - Kidneys are significantly affected by profound anatomic and functional changes with senescence. These changes lead to decline in glomerular filtration rate, decreased urinary concentrating and diluting ability, diminished urinary acidification, and impaired potassium clearance, to list a few. Such changes make the elderly prone to drug toxicity and serious fluid and electrolyte imbalance. While the entire mystery of aging is far from being clear, the role of oxidative stress, telomere length, Klotho gene expression, and the renin angiotensin system seem to be the key mechanisms involved in aging. Aging, being a complex process, involves an array of intertwined molecular pathways. Simultaneous study of multiple molecular pathways in parallel could provide invaluable information in understanding the clinical course of kidney aging and elucidating mechanisms that play key roles in the aging process. A better understanding of these mechanisms may help to preserve renal function, improve morbidity and mortality, and hopefully reduce healthcare costs for the aging population.
AB - Kidneys are significantly affected by profound anatomic and functional changes with senescence. These changes lead to decline in glomerular filtration rate, decreased urinary concentrating and diluting ability, diminished urinary acidification, and impaired potassium clearance, to list a few. Such changes make the elderly prone to drug toxicity and serious fluid and electrolyte imbalance. While the entire mystery of aging is far from being clear, the role of oxidative stress, telomere length, Klotho gene expression, and the renin angiotensin system seem to be the key mechanisms involved in aging. Aging, being a complex process, involves an array of intertwined molecular pathways. Simultaneous study of multiple molecular pathways in parallel could provide invaluable information in understanding the clinical course of kidney aging and elucidating mechanisms that play key roles in the aging process. A better understanding of these mechanisms may help to preserve renal function, improve morbidity and mortality, and hopefully reduce healthcare costs for the aging population.
KW - Aging
KW - Geriatric nephrology
KW - Klotho
KW - Oxidative stress
KW - Renal pathology
KW - Senescence
KW - Telomeres
UR - http://www.scopus.com/inward/record.url?scp=48549095189&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=48549095189&partnerID=8YFLogxK
U2 - 10.1007/s11255-008-9405-0
DO - 10.1007/s11255-008-9405-0
M3 - Review article
C2 - 18584301
AN - SCOPUS:48549095189
SN - 0301-1623
VL - 40
SP - 823
EP - 839
JO - International Urology and Nephrology
JF - International Urology and Nephrology
IS - 3
ER -