Renal Regeneration: The Bioengineering Approach

Marcus Salvatori; Andrea Peloso; Timil Patel; Sij Hemal; Joao Paulo Zambon; Ravi Katari; Giuseppe Orlando

doi:10.1016/B978-0-12-398523-1.00017-3

Renal Regeneration: The Bioengineering Approach

Marcus Salvatori, Andrea Peloso, Timil Patel, Sij Hemal, Joao Paulo Zambon, Ravi Katari, Giuseppe Orlando

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

The prevalence of chronic kidney disease continues to outpace the development of effective treatment strategies. For patients with advanced disease, renal replacement therapies approximate the filtration functions of the kidney at considerable cost and inconvenience, while failing to restore the resorptive and endocrine functions. Allogeneic transplantation remains the only restorative treatment, but donor shortage, surgical morbidity, and the need for lifelong immunosuppression significantly limit clinical application. Emerging technologies in the fields of regenerative medicine and tissue engineering strive to address these limitations. In the present chapter, we will illustrate the recent advances in kidney bioengineering and regeneration with an emphasis to the bioengineering approach. Collaborative efforts aim to produce a bioengineered kidney capable of restoring renal function in patients with end-stage disease.

Original language	English (US)
Title of host publication	Regenerative Medicine Applications in Organ Transplantation
Publisher	Elsevier Inc.
Pages	227-239
Number of pages	13
ISBN (Print)	9780123985231
DOIs	https://doi.org/10.1016/B978-0-12-398523-1.00017-3
State	Published - Jan 1 2014

Keywords

Cell
Extracellular matrix
Kidney bioengineering
Organ transplantation

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1016/B978-0-12-398523-1.00017-3

Cite this

@inbook{f5dc94dace474efab123a1adb84f68d1,

title = "Renal Regeneration: The Bioengineering Approach",

abstract = "The prevalence of chronic kidney disease continues to outpace the development of effective treatment strategies. For patients with advanced disease, renal replacement therapies approximate the filtration functions of the kidney at considerable cost and inconvenience, while failing to restore the resorptive and endocrine functions. Allogeneic transplantation remains the only restorative treatment, but donor shortage, surgical morbidity, and the need for lifelong immunosuppression significantly limit clinical application. Emerging technologies in the fields of regenerative medicine and tissue engineering strive to address these limitations. In the present chapter, we will illustrate the recent advances in kidney bioengineering and regeneration with an emphasis to the bioengineering approach. Collaborative efforts aim to produce a bioengineered kidney capable of restoring renal function in patients with end-stage disease.",

keywords = "Cell, Extracellular matrix, Kidney bioengineering, Organ transplantation",

author = "Marcus Salvatori and Andrea Peloso and Timil Patel and Sij Hemal and Zambon, {Joao Paulo} and Ravi Katari and Giuseppe Orlando",

year = "2014",

month = jan,

day = "1",

doi = "10.1016/B978-0-12-398523-1.00017-3",

language = "English (US)",

isbn = "9780123985231",

pages = "227--239",

booktitle = "Regenerative Medicine Applications in Organ Transplantation",

publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Renal Regeneration

T2 - The Bioengineering Approach

AU - Salvatori, Marcus

AU - Peloso, Andrea

AU - Patel, Timil

AU - Hemal, Sij

AU - Zambon, Joao Paulo

AU - Katari, Ravi

AU - Orlando, Giuseppe

PY - 2014/1/1

Y1 - 2014/1/1

N2 - The prevalence of chronic kidney disease continues to outpace the development of effective treatment strategies. For patients with advanced disease, renal replacement therapies approximate the filtration functions of the kidney at considerable cost and inconvenience, while failing to restore the resorptive and endocrine functions. Allogeneic transplantation remains the only restorative treatment, but donor shortage, surgical morbidity, and the need for lifelong immunosuppression significantly limit clinical application. Emerging technologies in the fields of regenerative medicine and tissue engineering strive to address these limitations. In the present chapter, we will illustrate the recent advances in kidney bioengineering and regeneration with an emphasis to the bioengineering approach. Collaborative efforts aim to produce a bioengineered kidney capable of restoring renal function in patients with end-stage disease.

AB - The prevalence of chronic kidney disease continues to outpace the development of effective treatment strategies. For patients with advanced disease, renal replacement therapies approximate the filtration functions of the kidney at considerable cost and inconvenience, while failing to restore the resorptive and endocrine functions. Allogeneic transplantation remains the only restorative treatment, but donor shortage, surgical morbidity, and the need for lifelong immunosuppression significantly limit clinical application. Emerging technologies in the fields of regenerative medicine and tissue engineering strive to address these limitations. In the present chapter, we will illustrate the recent advances in kidney bioengineering and regeneration with an emphasis to the bioengineering approach. Collaborative efforts aim to produce a bioengineered kidney capable of restoring renal function in patients with end-stage disease.

KW - Cell

KW - Extracellular matrix

KW - Kidney bioengineering

KW - Organ transplantation

UR - http://www.scopus.com/inward/record.url?scp=84902919657&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902919657&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-398523-1.00017-3

DO - 10.1016/B978-0-12-398523-1.00017-3

M3 - Chapter

AN - SCOPUS:84902919657

SN - 9780123985231

SP - 227

EP - 239

BT - Regenerative Medicine Applications in Organ Transplantation

PB - Elsevier Inc.

ER -

Renal Regeneration: The Bioengineering Approach

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this