@article{f07372f359b7401eadd1c543c2d118cd,
title = "Renal microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid",
abstract = "Arachidonic acid is oxidized by the microsomal cytochrome P-450 monooxygenases of rabbit kidney cortex and medulla to products that include W and W-1 alcohols and several epoxyacids. In vivo administration of deoxycorticosterone acetate results in a time dependent and selective induction of the arachidonic acid W/W-1 oxygenase activity of cortex and medulla microsomal fractions (145% and 220% of controls, respectively). Initial segmental analysis shows the presence of an active epoxygenase activity in the isolated rabbit pars recta and its in vitro activation by p-aminohippuric acid.",
author = "L. Lapuerta and N. Chacos and Falck, {J. R.} and H. Jacobson and Capdevila, {J. H.}",
note = "Funding Information: From the Departments of tBiochemistry and :j:Molecular Genetics, Uniuersity of Texas Health Science Center at Dallas, 5323 Harry Hines, Dallas, Texas, and the §Diuision of Nephrology and IIDepartment of Biochemistry, Vanderbilt Uniuersity Medical Center, Nashuille, Tennessee. L. Lapuerta was a Chilton Foundation Research Fellow. This work was supported by USPHS NIADDKD-38226. Reprint requests: J. H. Capdeuila, Diuision of Nephrology, Vanderbilt Uniuersity, Medical Center North S-3223, Nashuille TN 37232. * A preliminary report of parts of this work was presented at the 18th Annual Meeting of the American Society of Nephrology in New Orleans, Louisiana, December 1985.",
year = "1988",
doi = "10.1097/00000441-198804000-00010",
language = "English (US)",
volume = "295",
pages = "275--279",
journal = "American Journal of the Medical Sciences",
issn = "0002-9629",
publisher = "Lippincott Williams and Wilkins",
number = "4",
}