Abstract
An efficient, robust and highly enantioselective catalytic desymmetrization of 2,2-disubstituted cyclopentene-1,3-diones is developed via direct vinylogous nucleophilic addition of deconjugated butenolides. A remarkable influence of the secondary catalyst site on the enantioselectivity points towards an intriguing mechanistic scenario, possibly by triggering a change in catalyst conformation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1627-1633 |
| Number of pages | 7 |
| Journal | Chemical Science |
| Volume | 5 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2014 |
| Externally published | Yes |
ASJC Scopus subject areas
- Chemistry(all)