Relationship of butaperazine blood levels to plasma prolactin in chronic schizophrenic patients

Robert C. Smith; Carol A. Tamminga; John W. Crayton; Haroutune Dekirmenjian; John M. Davis

doi:10.1007/BF00431985

Relationship of butaperazine blood levels to plasma prolactin in chronic schizophrenic patients

Robert C. Smith, Carol A. Tamminga, John W. Crayton, Haroutune Dekirmenjian, John M. Davis

Research output: Contribution to journal › Article › peer-review

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Abstract

The relationship of plasma prolactin to plasma or red blood cell butaperazine levels was investigated in chronic schizophrenic patients treated with clinical doses of butaperazine, both after a single acute dose of the drug and during regular, twice daily butaperazine administration. Although there was a significant curvilinear relationship between peak plasma butaperazine levels after an acute single oral dose of butaperazine and the maximum prolactin response that we measured, steady-state levels of plasma or red cell butaperazine and plasma prolactin were not related. We conclude that plasma prolactin cannot be used as a substitute for or even as a rough indicator of butaperazine blood levels in chronic schizophrenic patients being treated with clinical doses of butaperazine.

Original language	English (US)
Pages (from-to)	29-33
Number of pages	5
Journal	Psychopharmacology
Volume	66
Issue number	1
DOIs	https://doi.org/10.1007/BF00431985
State	Published - Nov 1 1979

Keywords

Blood levels
Butaperazine
Prolactin

ASJC Scopus subject areas

Pharmacology

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10.1007/BF00431985

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abstract = "The relationship of plasma prolactin to plasma or red blood cell butaperazine levels was investigated in chronic schizophrenic patients treated with clinical doses of butaperazine, both after a single acute dose of the drug and during regular, twice daily butaperazine administration. Although there was a significant curvilinear relationship between peak plasma butaperazine levels after an acute single oral dose of butaperazine and the maximum prolactin response that we measured, steady-state levels of plasma or red cell butaperazine and plasma prolactin were not related. We conclude that plasma prolactin cannot be used as a substitute for or even as a rough indicator of butaperazine blood levels in chronic schizophrenic patients being treated with clinical doses of butaperazine.",

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AU - Smith, Robert C.

AU - Tamminga, Carol A.

AU - Crayton, John W.

AU - Dekirmenjian, Haroutune

AU - Davis, John M.

PY - 1979/11/1

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N2 - The relationship of plasma prolactin to plasma or red blood cell butaperazine levels was investigated in chronic schizophrenic patients treated with clinical doses of butaperazine, both after a single acute dose of the drug and during regular, twice daily butaperazine administration. Although there was a significant curvilinear relationship between peak plasma butaperazine levels after an acute single oral dose of butaperazine and the maximum prolactin response that we measured, steady-state levels of plasma or red cell butaperazine and plasma prolactin were not related. We conclude that plasma prolactin cannot be used as a substitute for or even as a rough indicator of butaperazine blood levels in chronic schizophrenic patients being treated with clinical doses of butaperazine.

AB - The relationship of plasma prolactin to plasma or red blood cell butaperazine levels was investigated in chronic schizophrenic patients treated with clinical doses of butaperazine, both after a single acute dose of the drug and during regular, twice daily butaperazine administration. Although there was a significant curvilinear relationship between peak plasma butaperazine levels after an acute single oral dose of butaperazine and the maximum prolactin response that we measured, steady-state levels of plasma or red cell butaperazine and plasma prolactin were not related. We conclude that plasma prolactin cannot be used as a substitute for or even as a rough indicator of butaperazine blood levels in chronic schizophrenic patients being treated with clinical doses of butaperazine.

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KW - Prolactin

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Relationship of butaperazine blood levels to plasma prolactin in chronic schizophrenic patients

Abstract

Keywords

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