Reintervention Is Associated With Improved Survival in Pediatric Patients With Pulmonary Vein Stenosis

Melinda J. Cory, Yinn K. Ooi, Michael S. Kelleman, Robert N. Vincent, Dennis W. Kim, Christopher J. Petit

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Objectives The aim of this study was to evaluate survival following catheter intervention in pediatric patients with pulmonary vein stenosis (PVS). Background Despite aggressive surgical and catheter intervention on PVS in children, recurrence and progression of stenosis can lead to right heart failure and death. Clinicians continue to seek effective treatment options for PVS. Methods A single-center, retrospective study was performed including all patients <18 years of age who underwent catheter intervention (balloon angioplasty and bare-metal stent and drug-eluting stent insertion) on PVS. Endpoints included death, vein loss, and rate of reintervention. Results Thirty patients underwent intervention (balloon angioplasty, n = 9; bare-metal stent, n = 5; drug-eluting stent, n = 16) at a median age of 6.4 months (4.3 to 9.9 months). Median follow-up duration was 30.6 months (77 days to 10.5 years). Fourteen patients (47%) died at a median of 2.0 months (0.4 to 3.2 months) following intervention. There was no association between DES placement and survival (p = 0.067). Reintervention (catheter or surgical) was associated with improved survival (p = 0.001), with a 1-year survival rate of 84% compared with 25% for no reintervention. Vein loss occurred in 34 of 58 (59%) veins at a median of 3.3 months (1.0 to 5.0 months). One-year vein survival was higher with DES implantation (p = 0.031) and with reintervention (p < 0.001). Conclusions DES implantation at first catheter intervention appears to be associated with improved vein survival but may not result in improved patient survival. However, reintervention appears to be associated with improved patient survival and vein patency, suggesting that despite mode of treatment, frequent surveillance is important in the care of these patients.

Original languageEnglish (US)
Pages (from-to)1788-1798
Number of pages11
JournalJACC: Cardiovascular Interventions
Issue number17
StatePublished - Sep 11 2017
Externally publishedYes


  • balloon angioplasty
  • drug-eluting stent(s)
  • endovascular stent(s)
  • pulmonary vein stenosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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