Regulation of the mevalonate pathway

Joseph L. Goldstein; Michael S. Brown

doi:10.1038/343425a0

Regulation of the mevalonate pathway

Joseph L. Goldstein, Michael S. Brown

Research output: Contribution to journal › Review article › peer-review

4869 Scopus citations

Abstract

The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of cancer as well as heart disease.

Original language	English (US)
Pages (from-to)	425-430
Number of pages	6
Journal	Nature
Volume	343
Issue number	6257
DOIs	https://doi.org/10.1038/343425a0
State	Published - 1990

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title = "Regulation of the mevalonate pathway",

abstract = "The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of cancer as well as heart disease.",

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AB - The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of cancer as well as heart disease.

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DO - 10.1038/343425a0

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JO - Nature

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Regulation of the mevalonate pathway

Abstract

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