Regulation of proximal reabsorption by effective arterial blood volume

D. W. Seldin, P. A. Preisig, R. J. Alpern

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


In summary, effective arterial volume is able to regulate the transport of NaCl, NaHCO3, and organic solutes in the proximal tubule. These effects are mediated by changes in renal hemodynamics that secondarily modify proximal tubular transport through changes in interstitial hydrostatic and oncotic pressure, changes in the levels of hormones such as angiotensin II, epinephrine, norepinephrine, dopamine, and atrial natriuretic factor, and changes in renal nerve activity. In addition, there are chronic effects of dietary NaCl, the mechanisms of which have yet to be determined.

Original languageEnglish (US)
Pages (from-to)212-219
Number of pages8
JournalSeminars in nephrology
Issue number2
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Nephrology


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