TY - JOUR
T1 - Regulation of murine class I genes by interferons is controlled by regions located both 5' and 3' to the transcription initiation site
AU - Korber, B.
AU - Hood, L.
AU - Stroynowski, I.
PY - 1987
Y1 - 1987
N2 - Interferons regulate the expression of a large number of mammalian genes, including the major histocompatibility antigen genes. To investigate the mechanisms involved in interferon action, we have analyzed the ability of murine H-2L(d) and H-2D(d) DNA sequences to control the responses to interferon. The results indicate that interferon regulation of class I gene expression is complex and involves at least two mechanisms that are dependent on class I sequences located upstream and downstream to the transcription initiation site. In transfected mouse L cells, both of these regions are required for full enhancement of class I gene expression, with the major portion of the response controlled by the sequences located 3' to the transcription initiation site. The fine-mapping analysis of the 5' region-encoded response also suggests that recombinant α and γ interferons may exert their effects on class I gene expression by using different cis-acting regulatory sequences.
AB - Interferons regulate the expression of a large number of mammalian genes, including the major histocompatibility antigen genes. To investigate the mechanisms involved in interferon action, we have analyzed the ability of murine H-2L(d) and H-2D(d) DNA sequences to control the responses to interferon. The results indicate that interferon regulation of class I gene expression is complex and involves at least two mechanisms that are dependent on class I sequences located upstream and downstream to the transcription initiation site. In transfected mouse L cells, both of these regions are required for full enhancement of class I gene expression, with the major portion of the response controlled by the sequences located 3' to the transcription initiation site. The fine-mapping analysis of the 5' region-encoded response also suggests that recombinant α and γ interferons may exert their effects on class I gene expression by using different cis-acting regulatory sequences.
UR - http://www.scopus.com/inward/record.url?scp=0023238926&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023238926&partnerID=8YFLogxK
U2 - 10.1073/pnas.84.10.3380
DO - 10.1073/pnas.84.10.3380
M3 - Article
C2 - 3106967
AN - SCOPUS:0023238926
SN - 0027-8424
VL - 84
SP - 3380
EP - 3384
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 10
ER -