Abstract
Andrqstenedione-1, 2-3H metabolism has been measured under standardized conditions in growing and resting hair roots from varying anatomical sites from 5 women and 12 men, 6 of whom had male pattern baldness. 5α-Reduced and 17β-hydroxysteroids were the major metabolites of androstenedione. Hairs from all body regions have the capacity to transform androstenedione into testosterone but the rate of the reduction of 17-ketosteroids is less than the rate of oxidation so that the 17-keto rather than 17β-hydroxysteroids tend to accumulate in the cell. Since the 5α-reduction is irreversible and conditions favor the formation of 17-ketosteroids, androstanedione is the principal intracellular androgen in the hair root.
Original language | English (US) |
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Pages (from-to) | 1012-1019 |
Number of pages | 8 |
Journal | Journal of Clinical Endocrinology and Metabolism |
Volume | 39 |
Issue number | 6 |
DOIs | |
State | Published - Dec 1974 |
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Biochemistry
- Endocrinology
- Clinical Biochemistry
- Biochemistry, medical