Regulation of cell lineage specification by the retinoblastoma tumor suppressor

S. X. Skapek, Y. R. Pan, E. Y H P Lee

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations


Early studies of the retinoblastoma gene (RB) have uncovered its critical role as a regulator of the G1/S cell cycle phase progression. Surprisingly, genetic approaches in mammals and nematodes have also shown RB controls cell lineage specification and aspects of differentiation. The RB gene product accomplishes this by diverse mechanisms such as by interacting with tissue-specific transcription factors, enhancing RNA interference, and modifying chromatin structure. We review recent studies uncovering novel mechanisms by which RB works in several cell lineages and we provide perspectives on how these new findings might relate to RB tumor suppression.

Original languageEnglish (US)
Pages (from-to)5268-5276
Number of pages9
Issue number38
StatePublished - Aug 28 2006


  • Cellular differentiation
  • Retinoblastoma susceptibility gene
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research


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