Regulation of cardiomyocyte autophagy by calcium

Soni Shaikh, Rodrigo Troncoso, Alfredo Criollo, Roberto Bravo-Sagua, Lorena García, Eugenia Morselli, Mariana Cifuentes, Andrew F G Quest, Joseph A Hill, Sergio Lavandero

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Calcium signaling plays a crucial role in a multitude of events within the cardiomyocyte, including cell cycle control, growth, apoptosis, and autophagy. With respect to calcium-dependent regulation of autophagy, ion channels and exchangers, receptors, and intracellular mediators play fundamental roles. In this review, we discuss calcium-dependent regulation of cardiomyocyte autophagy, a lysosomal mechanism that is often cytoprotective, serving to defend against disease-related stress and nutrient insufficiency. We also highlight the importance of the subcellular distribution of calcium and related proteins, interorganelle communication, and other key signaling events that govern cardiomyocyte autophagy.

Original languageEnglish (US)
Pages (from-to)E587-E596
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Issue number8
StatePublished - Apr 15 2016


  • Autophagy
  • Calcium
  • Cardiomyocyte
  • Heart
  • Interorganelle communication

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)


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