Regulation of bone and skeletal development by the SHP-2 protein tyrosine phosphatase

Nobuhiro Kamiya, Harry K W Kim, Philip D. King

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Src homology-2 protein tyrosine phosphatase (SHP-2) that is encoded by the PTPN11 gene in humans is an intracellular signaling molecule that couples growth factor receptors to activation of the Ras small GTP-binding protein that regulates cell growth, proliferation and differentiation. Germline mutations of PTPN11 are causative of Noonan syndrome and LEOPARD syndrome in humans in which there are recognized skeletal abnormalities that include growth retardation, spinal curvature and chest malformations. In addition, combined somatic and germline PTPN11 mutations have been shown to be responsible for a rare benign bone cartilaginous tumor disease known as metachondromatosis. In parallel, gene targeting studies performed in mice have revealed an essential role for SHP-2 as a regulator of bone and skeletal development. In this review the significance of these findings in mice to the understanding of the pathogenesis of skeletal abnormalities in humans with SHP-2 mutations is discussed.

Original languageEnglish (US)
Pages (from-to)55-60
Number of pages6
StatePublished - Nov 1 2014


  • Metachondromatosis
  • Ras signaling
  • SHP-2
  • Scoliosis
  • Skeletal deformity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Histology


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