Recent reports have demonstrated that small duplex RNAs mediate recognition of chromosomal DNA and inhibit transcription within mammalian cells. Key unresolved issues include whether RNAs directly bind to DNA, the identification of the mechanism(s) that convert chromosome recognition into gene silencing and whether naturally occurring antigene RNAs (agRNAs) exist.
|Original language||English (US)|
|Number of pages||4|
|Journal||Trends in biochemical sciences|
|State||Published - Dec 2005|
ASJC Scopus subject areas
- Molecular Biology