TY - JOUR
T1 - Refractive Growth of the Crystalline Lens in the Infant Aphakia Treatment Study
AU - Infant Aphakia Treatment Study Group
AU - McClatchey, Thaddeus S.
AU - Lambert, Scott R.
AU - Morrison, David G.
AU - Kruger, Stacey J.
AU - Wilson, Lorri B.
AU - McClatchey, Scott K.
AU - Dubois, Lindreth
AU - Nizam, Azhar
AU - Long, Qi
AU - Lynn, Michael J.
AU - Bridgman, Betsy
AU - Celano, Marianne
AU - Cleveland, Julia
AU - Cotsonis, George
AU - Drews-Botsch, Carey
AU - Freret, Nana
AU - Lu, Lu
AU - Swanson, Seegar
AU - Tutu-Gxashe, Thandeka
AU - Hartmann, E. Eugenie
AU - Carrigan, Anna K.
AU - Edwards, Clara
AU - Busettini, Claudio
AU - Hayley, Samuel
AU - Lewis, Eleanor
AU - Joost Felius, Alicia Kindred
AU - Buckley, Edward G.
AU - Plager, David A.
AU - Wilson, M. Edward
AU - Drews-Botsch, Carolyn
AU - Everett, Donald F.
AU - Felius, Joost
AU - Bozic, Margaret
AU - Holleschau, Ann
AU - Russell, Buddy
AU - Ward, Michael
AU - Bradham, Carol
AU - Vanderveen, Deborah K.
AU - Mansfield, Theresa A.
AU - Miller, Kathryn Bisceglia
AU - Winter, Tamar
AU - Christiansen, Stephen P.
AU - Bothun, Erick D.
AU - Jedlicka, Jason
AU - Winters, Patricia
AU - Lang, Jacob
AU - Anderson, Jill S.
AU - Traboulsi, Elias I.
AU - Crowe, Susan
AU - Weakley, David R.
N1 - Publisher Copyright:
© 2022 American Academy of Ophthalmology
PY - 2022/12
Y1 - 2022/12
N2 - Objective: To compare the rate of refractive growth (RRG3) of the crystalline lens (“lens”) versus the eye excluding the lens (“globe”) for the fellow, noncataractous eyes of participants in the Infant Aphakia Treatment Study. Design: Retrospective cohort study. Subjects: A total of 114 children who had unilateral cataract surgery as infants were recruited. Biometric and refraction data were obtained from the normal eyes at surgery and at 1, 5, and 10 years. Subjects were included if complete data (axial length [AL], corneal power, and refraction) were available at surgery and at 10 years of age. Methods: At surgery and at 1, 5, and 10 years, AL, corneal power, and cycloplegic refraction were measured in the normal eyes. For each eye, the RRG3 was defined by linear regression of refraction at the intraocular lens (IOL) plane against log10 (age + 0.6 years). The RRG3 for the globe was based on IOL power for emmetropia; the RRG3 for the lens was based on IOL power calculated to give the observed refractions. Intraocular lens powers were calculated with the Holladay 1 formula. The means were compared with a paired 2-tailed t test, and linear regression was used to look for a correlation between RRG3 of the lens globe. Main Outcome Measures: The RRG3 of the lens and globe. Results: Complete data were available for 107 normal eyes. The mean RRG3 of the lenses was −12.0 ± 2.5 diopters (D) and the mean RRG3 of the globes was −14.1 ± 2.7 D (P < 0.001). The RRG3 of the lens correlated with the RRG3 of the globe (R2 = 0.25, P < 0.001). Conclusions: The RRG3 was 2 D more negative in globes compared with lenses in normal eyes. Globes with a greater rate of growth tended to have lenses with a greater rate of growth.
AB - Objective: To compare the rate of refractive growth (RRG3) of the crystalline lens (“lens”) versus the eye excluding the lens (“globe”) for the fellow, noncataractous eyes of participants in the Infant Aphakia Treatment Study. Design: Retrospective cohort study. Subjects: A total of 114 children who had unilateral cataract surgery as infants were recruited. Biometric and refraction data were obtained from the normal eyes at surgery and at 1, 5, and 10 years. Subjects were included if complete data (axial length [AL], corneal power, and refraction) were available at surgery and at 10 years of age. Methods: At surgery and at 1, 5, and 10 years, AL, corneal power, and cycloplegic refraction were measured in the normal eyes. For each eye, the RRG3 was defined by linear regression of refraction at the intraocular lens (IOL) plane against log10 (age + 0.6 years). The RRG3 for the globe was based on IOL power for emmetropia; the RRG3 for the lens was based on IOL power calculated to give the observed refractions. Intraocular lens powers were calculated with the Holladay 1 formula. The means were compared with a paired 2-tailed t test, and linear regression was used to look for a correlation between RRG3 of the lens globe. Main Outcome Measures: The RRG3 of the lens and globe. Results: Complete data were available for 107 normal eyes. The mean RRG3 of the lenses was −12.0 ± 2.5 diopters (D) and the mean RRG3 of the globes was −14.1 ± 2.7 D (P < 0.001). The RRG3 of the lens correlated with the RRG3 of the globe (R2 = 0.25, P < 0.001). Conclusions: The RRG3 was 2 D more negative in globes compared with lenses in normal eyes. Globes with a greater rate of growth tended to have lenses with a greater rate of growth.
KW - IATS
KW - Ocular development
KW - Pediatric cataract surgery
KW - RRG3
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U2 - 10.1016/j.xops.2022.100208
DO - 10.1016/j.xops.2022.100208
M3 - Article
C2 - 36531580
AN - SCOPUS:85149610058
SN - 2666-9145
VL - 2
JO - Ophthalmology Science
JF - Ophthalmology Science
IS - 4
M1 - 100208
ER -