Redesigning nature's poisons to create anti-tumor reagents

Ellen S. Vitetta, R. Jerrold Fulton, Richard D. May, Mark Till, Jonathan W. Uhr

Research output: Contribution to journalArticlepeer-review

287 Scopus citations


Immunotoxins are conjugates of cell-reactive antibodies and toxins or their subunits. In this report, the chemistry, biology, pharmacokinetics, and anti-tumor effects of first generation immunotoxins; the preparation of improved second generation immunotoxins that display greater anti-tumor efficacy; and the role of genetic engineering in creating third-generation immunotoxins are discussed.

Original languageEnglish (US)
Pages (from-to)1098-1104
Number of pages7
Issue number4830
StatePublished - 1987

ASJC Scopus subject areas

  • General


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