Receptor-interacting protein (RIP) kinase family

Duanwu Zhang, Juan Lin, Jiahuai Han

Research output: Contribution to journalArticlepeer-review

145 Scopus citations


Receptor-interacting protein (RIP) kinases are a group of threonine/serine protein kinases with a relatively conserved kinase domain but distinct non-kinase regions. A number of different domain structures, such as death and caspase activation and recruitment domain (CARD) domains, were found in different RIP family members, and these domains should be keys in determining the specific function of each RIP kinase. It is known that RIP kinases participate in different biological processes, including those in innate immunity, but their downstream substrates are largely unknown. This review will give an overview of the structures and functions of RIP family members, and an update of recent progress in RIP kinase research.

Original languageEnglish (US)
Pages (from-to)243-249
Number of pages7
JournalCellular and Molecular Immunology
Issue number4
StatePublished - Jul 2010


  • RIP
  • TNF
  • apoptosis
  • kinase
  • necrosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases


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