Recent total syntheses of anthraquinone-based natural products

Jackson A. Gartman; Uttam K. Tambar

doi:10.1016/j.tet.2021.132501

Recent total syntheses of anthraquinone-based natural products

Jackson A. Gartman, Uttam K. Tambar

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

The scientific community has found deep interest in anthraquinone-based compounds due to their therapeutic properties and challenging structural elements. Various architecturally beautiful natural products have been successfully synthesized in recent decades utilizing two main strategies: either an early-stage synthesis of the anthraquinone and further elongation of the system, or a late-stage introduction of the anthraquinone ring moiety. Select syntheses of complex anthraquinone monomers and dimers within the past 20 years are described with an emphasis on the retrosynthetic disconnections that shape the anthraquinone-installation strategy.

Original language	English (US)
Article number	132501
Journal	Tetrahedron
Volume	105
DOIs	https://doi.org/10.1016/j.tet.2021.132501
State	Published - Jan 22 2022

Keywords

Annulation
Anthraquinones
Cyclization
Cycloaddition
Natural products
Total synthesis

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tet.2021.132501

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title = "Recent total syntheses of anthraquinone-based natural products",

abstract = "The scientific community has found deep interest in anthraquinone-based compounds due to their therapeutic properties and challenging structural elements. Various architecturally beautiful natural products have been successfully synthesized in recent decades utilizing two main strategies: either an early-stage synthesis of the anthraquinone and further elongation of the system, or a late-stage introduction of the anthraquinone ring moiety. Select syntheses of complex anthraquinone monomers and dimers within the past 20 years are described with an emphasis on the retrosynthetic disconnections that shape the anthraquinone-installation strategy.",

keywords = "Annulation, Anthraquinones, Cyclization, Cycloaddition, Natural products, Total synthesis",

author = "Gartman, {Jackson A.} and Tambar, {Uttam K.}",

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AU - Tambar, Uttam K.

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N2 - The scientific community has found deep interest in anthraquinone-based compounds due to their therapeutic properties and challenging structural elements. Various architecturally beautiful natural products have been successfully synthesized in recent decades utilizing two main strategies: either an early-stage synthesis of the anthraquinone and further elongation of the system, or a late-stage introduction of the anthraquinone ring moiety. Select syntheses of complex anthraquinone monomers and dimers within the past 20 years are described with an emphasis on the retrosynthetic disconnections that shape the anthraquinone-installation strategy.

AB - The scientific community has found deep interest in anthraquinone-based compounds due to their therapeutic properties and challenging structural elements. Various architecturally beautiful natural products have been successfully synthesized in recent decades utilizing two main strategies: either an early-stage synthesis of the anthraquinone and further elongation of the system, or a late-stage introduction of the anthraquinone ring moiety. Select syntheses of complex anthraquinone monomers and dimers within the past 20 years are described with an emphasis on the retrosynthetic disconnections that shape the anthraquinone-installation strategy.

KW - Annulation

KW - Anthraquinones

KW - Cyclization

KW - Cycloaddition

KW - Natural products

KW - Total synthesis

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DO - 10.1016/j.tet.2021.132501

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VL - 105

JO - Tetrahedron

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ER -

Recent total syntheses of anthraquinone-based natural products

Abstract

Keywords

ASJC Scopus subject areas

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