Real-time three-dimensional Fourier-domain optical coherence tomography video image guided microsurgeries

Jin U. Kang, Yong Huang, Kang Zhang, Zuhaib Ibrahim, Jaepyeong Cha, W. P.Andrew Lee, Gerald Brandacher, Peter L. Gehlbach

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


The authors describe the development of an ultrafast three-dimensional (3D) optical coherence tomography (OCT) imaging system that provides real-time intraoperative video images of the surgical site to assist surgeons during microsurgical procedures. This system is based on a full-range complex conjugate free Fourierdomain OCT (FD-OCT). The system was built in a CPU-GPU heterogeneous computing architecture capable of video OCT image processing. The system displays at a maximum speed of 10 volume/s for an image volume size of 160 × 80 × 1024 (X × Y × Z) pixels. We have used this system to visualize and guide two prototypical microsurgical maneuvers: microvascular anastomosis of the rat femoral artery and ultramicrovascular isolation of the retinal arterioles of the bovine retina. Our preliminary experiments using 3D-OCT-guided microvascular anastomosis showed optimal visualization of the rat femoral artery (diameter < 0.8 mm), instruments, and suture material. Real-time intraoperative guidance helped facilitate precise suture placement due to optimized views of the vessel wall during anastomosis. Using the bovine retina as a model system, we have performed "ultra microvascular" feasibility studies by guiding handheld surgical micro-instruments to isolate retinal arterioles (diameter ~0.1 mm). Isolation of the microvessels was confirmed by successfully passing a suture beneath the vessel in the 3D imaging environment.

Original languageEnglish (US)
Article number081403
JournalJournal of biomedical optics
Issue number8
StatePublished - Aug 2012
Externally publishedYes


  • Fiber optic sensor
  • Medical optics instrumentation
  • Optical coherence tomography
  • Optical imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Biomedical Engineering


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