Reactive nitrogen intermediates and the pathogenesis of Salmonella and Mycobacteria

Michael U. Shiloh, Carl F. Nathan

Research output: Contribution to journalReview articlepeer-review

137 Scopus citations


Over the past decade, reactive nitrogen intermediates joined reactive oxygen intermediates as a biochemically parallel and functionally non- redundant pathway for mammalian host resistance to many microbial pathogens. The past year has brought a new appreciation that these two pathways are partially redundant, such that each can compensate in part for the absence of the other. In combination, their importance to defense of the murine host is greater than previously appreciated. In addition to direct microbicidal actions, reactive nitrogen intermediates have immunoregulatory effects relevant to the control of infection. Genes have been characterized in Mycobacterium tuberculosis and Salmonella typhimurium that may regulate the ability of pathogens to resist reactive nitrogen and oxygen intermediates produced by activated macrophages.

Original languageEnglish (US)
Pages (from-to)35-42
Number of pages8
JournalCurrent Opinion in Microbiology
Issue number1
StatePublished - Feb 1 2000

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases


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