RB tumor suppressive function in response to xenobiotic hepatocarcinogens

Christopher Reed, Jack Hutcheson, Christopher N. Mayhew, Agnieszka K. Witkiewicz, Erik S. Knudsen

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Diverse etiologic events are associated with the development of hepatocellular carcinoma. During hepatocarcinogenesis, genetic events likely occur that subsequently cooperate with long-term exposures to further drive the progression of hepatocellular carcinoma. In this study, the frequent loss of the retinoblastoma (RB) tumor suppressor in hepatocellular carcinoma was modeled in response to diverse hepatic stresses. Loss of RB did not significantly affect the response to a steatotic stress as driven by a methionine- and choline-deficient diet. In addition, RB status did not significantly influence the response to peroxisome proliferators that can drive hepatomegaly and tumor development in rodents. However, RB loss exhibited a highly significant effect on the response to the xenobiotic1,4-Bis-[2-(3,5-dichloropyridyloxy)] benzene. Loss of RB yielded a unique proliferative response to this agent, which was distinct from both regenerative stresses and genotoxic carcinogens. Long-term exposure to 1,4-Bis-[2-(3,5-dichloropyridyloxy)] benzene yielded profound tumor development in RB-deficient livers that was principally absent in RB-sufficient tissue. These data demonstrate the context specificity of RB and the key role RB plays in the suppression of hepatocellular carcinoma driven by xenobiotic stress.

Original languageEnglish (US)
Pages (from-to)1853-1859
Number of pages7
JournalAmerican Journal of Pathology
Issue number6
StatePublished - Jun 2014

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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