Raptor protein contains a caspase-like domain

Krzysztof Ginalski, Hong Zhang, Nick V. Grishin

Research output: Contribution to journalShort surveypeer-review

19 Scopus citations


Using state-of-the-art sequence analysis and structure-prediction methods a caspase-like domain in the N-terminal region of raptor proteins has been identified. This domain, which is characterized by the presence of invariant catalytic Cys-His dyad, is evolutionarily and structurally related to known caspases and might have protease activity. This finding suggests several unexpected aspects of raptor function in the target of rapamycin (TOR) signaling pathway.

Original languageEnglish (US)
Pages (from-to)522-524
Number of pages3
JournalTrends in Biochemical Sciences
Issue number10
StatePublished - Oct 1 2004

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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