TY - JOUR
T1 - Rapid, noninvasive quantitation of skin disease in systemic sclerosis using optical coherence elastography
AU - Du, Yong
AU - Liu, Chih Hao
AU - Lei, Ling
AU - Singh, Manmohan
AU - Li, Jiasong
AU - Hicks, M. John
AU - Larin, Kirill V.
AU - Mohan, Chandra
N1 - Funding Information:
The authors are grateful to Mr. Chen Wu and Ms. Rasksha Raghunathan for experimental assistance, and to Dr. Zhaolong Han for the discussion of biomechanical skin properties. This work was supported in part by NIH R01 DK81872 (C.M.) and R01 EY022362, R01 HL120140, R01 HD086765, and U54 HG006348 (K.L.). The authors do not have any financial conflict of interest with respect to this study.
Publisher Copyright:
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE).
PY - 2016/4/30
Y1 - 2016/4/30
N2 - Systemic sclerosis (SSc) is a connective tissue disease that results in excessive accumulation of collagen in the skin and internal organs. Overall, SSc has a rare morbidity (276 cases per million adults in the United States), but has a 10-year survival rate of 55%. Currently, the modified Rodnan skin score (mRSS) is assessed by palpation on 17 sites on the body. However, the mRSS assessed score is subjective and may be influenced by the experience of the rheumatologists. In addition, the inherent elasticity of skin may bias the mRSS assessment in the early stage of SSc, such as oedematous. Optical coherence elastography (OCE) is a rapidly emerging technique, which can assess mechanical contrast in tissues with micrometer spatial resolution. In this work, the OCE technique is applied to assess the mechanical properties of skin in both control and bleomycin (BLM) induced SSc-like disease noninvasively. Young's modulus of the BLM-SSc skin was found be significantly higher than that of normal skin, in both the in vivo and in vitro studies (p<0.05). Thus, OCE is able to differentiate healthy and fibrotic skin using mechanical contrast. It is a promising new technology for quantifying skin involvement in SSc in a rapid, unbiased, and noninvasive manner.
AB - Systemic sclerosis (SSc) is a connective tissue disease that results in excessive accumulation of collagen in the skin and internal organs. Overall, SSc has a rare morbidity (276 cases per million adults in the United States), but has a 10-year survival rate of 55%. Currently, the modified Rodnan skin score (mRSS) is assessed by palpation on 17 sites on the body. However, the mRSS assessed score is subjective and may be influenced by the experience of the rheumatologists. In addition, the inherent elasticity of skin may bias the mRSS assessment in the early stage of SSc, such as oedematous. Optical coherence elastography (OCE) is a rapidly emerging technique, which can assess mechanical contrast in tissues with micrometer spatial resolution. In this work, the OCE technique is applied to assess the mechanical properties of skin in both control and bleomycin (BLM) induced SSc-like disease noninvasively. Young's modulus of the BLM-SSc skin was found be significantly higher than that of normal skin, in both the in vivo and in vitro studies (p<0.05). Thus, OCE is able to differentiate healthy and fibrotic skin using mechanical contrast. It is a promising new technology for quantifying skin involvement in SSc in a rapid, unbiased, and noninvasive manner.
KW - dermatology
KW - elastic wave velocity
KW - elasticity
KW - optical coherence elastography
KW - scleroderma
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U2 - 10.1117/1.JBO.21.4.046002
DO - 10.1117/1.JBO.21.4.046002
M3 - Article
C2 - 27048877
AN - SCOPUS:84964455483
SN - 1083-3668
VL - 21
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
IS - 4
M1 - 046002
ER -