Rapid Inhibition of Pyruvate Dehydrogenase: An Initiating Event in High Dietary Fat-Induced Loss of Metabolic Flexibility in the Heart

Agriculture & Biology

• pyruvate dehydrogenase (lipoamide) 100%
• pyruvate dehydrogenase (acetyl-transferring) kinase 97%
• dietary fat 78%
• heart 59%
• fatty acids 42%
• diet 39%
• mitochondria 34%
• high fat diet 33%
• pyruvates 30%
• insulin 26%
• mice 26%
• oxidation 22%
• glucose transporters 20%
• low fat diet 19%
• glucose 18%
• energy 18%
• cardiac output 18%
• cardiovascular diseases 16%
• phosphorylation 13%
• lipids 8%
• enzymes 6%

Medicine & Life Sciences

• Dietary Fats 91%
• pyruvate dehydrogenase kinase 4 86%
• Pyruvic Acid 82%
• Oxidoreductases 70%
• Heart 49%
• Diet 43%
• Fatty Acids 43%
• Mitochondria 31%
• High Fat Diet 25%
• Glucose Transporter Type 4 18%
• Insulin 17%
• Fat-Restricted Diet 16%
• Glucose 16%
• Knockout Mice 11%
• Fats 9%
• Cardiovascular Diseases 9%
• Phosphorylation 8%
• Enzymes 6%

Chemical Compounds

• Pyruvate 79%
• Metabolic 62%
• Flexibility 60%
• Fat 30%
• Fatty Acid 24%
• Glucose 16%
• Insulin Derivative 15%
• Energy 7%
• Oxidation Reaction 6%
• Reduction 3%