Ral GTPases: Corrupting the exocyst in cancer cells

Jacques H. Camonis, Michael A. White

Research output: Contribution to journalReview articlepeer-review

94 Scopus citations


The Ras-like small G-proteins RalA and RalB have achieved some notoriety as components of one of a growing variety of candidate Ras effector pathways. Recent work has demonstrated that Ral GTPase activation is required to support both the initiation and maintenance of tumorigenic transformation of human cells. The mechanistic basis for this support remains to be defined. However, the discovery that the exocyst is a direct effector complex for activated Ral proteins suggests that mobilization of polarized exocytosis might be a basic component of the biological framework supporting tumorigenic progression.

Original languageEnglish (US)
Pages (from-to)327-332
Number of pages6
JournalTrends in Cell Biology
Issue number6
StatePublished - Jun 2005

ASJC Scopus subject areas

  • Cell Biology


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