Quorum-sensing-regulated bActobolin Production by burkholderia thailandensis E264

Mohammad R. Seyedsayamdost; Josephine R. Chandler; Joshua A V Blodgett; Patricia S. Lima; Breck A. Duerkop; Ken Ichi Oinuma; E. Peter Greenberg; Jon Clardy

doi:10.1021/ol902751x

Quorum-sensing-regulated bActobolin Production by burkholderia thailandensis E264

Mohammad R. Seyedsayamdost, Josephine R. Chandler, Joshua A V Blodgett, Patricia S. Lima, Breck A. Duerkop, Ken Ichi Oinuma, E. Peter Greenberg, Jon Clardy

Immunology

Research output: Contribution to journal › Article › peer-review

88 Scopus citations

Abstract

(Figure Presented) Bacterial acyl-homoserlne lactones upregulated an uncharacterlzed gene cluster (bta) In Burkholderla thallandensls E264 to produce an uncharacterlzed polar antibiotic. The antibiotic Is Identified as a mixture of four bactobollns. Annotation of the bta cluster allows us to propose a blosynthetlc scheme for bactobolln and reveals unusual enzymatic reactions for further study.

Original language	English (US)
Pages (from-to)	716-719
Number of pages	4
Journal	Organic Letters
Volume	12
Issue number	4
DOIs	https://doi.org/10.1021/ol902751x
State	Published - Feb 19 2010

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol902751x

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title = "Quorum-sensing-regulated bActobolin Production by burkholderia thailandensis E264",

abstract = "(Figure Presented) Bacterial acyl-homoserlne lactones upregulated an uncharacterlzed gene cluster (bta) In Burkholderla thallandensls E264 to produce an uncharacterlzed polar antibiotic. The antibiotic Is Identified as a mixture of four bactobollns. Annotation of the bta cluster allows us to propose a blosynthetlc scheme for bactobolln and reveals unusual enzymatic reactions for further study.",

author = "Seyedsayamdost, {Mohammad R.} and Chandler, {Josephine R.} and Blodgett, {Joshua A V} and Lima, {Patricia S.} and Duerkop, {Breck A.} and Oinuma, {Ken Ichi} and {Peter Greenberg}, E. and Jon Clardy",

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doi = "10.1021/ol902751x",

language = "English (US)",

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journal = "Organic Letters",

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AU - Seyedsayamdost, Mohammad R.

AU - Chandler, Josephine R.

AU - Blodgett, Joshua A V

AU - Lima, Patricia S.

AU - Duerkop, Breck A.

AU - Oinuma, Ken Ichi

AU - Peter Greenberg, E.

AU - Clardy, Jon

PY - 2010/2/19

Y1 - 2010/2/19

N2 - (Figure Presented) Bacterial acyl-homoserlne lactones upregulated an uncharacterlzed gene cluster (bta) In Burkholderla thallandensls E264 to produce an uncharacterlzed polar antibiotic. The antibiotic Is Identified as a mixture of four bactobollns. Annotation of the bta cluster allows us to propose a blosynthetlc scheme for bactobolln and reveals unusual enzymatic reactions for further study.

AB - (Figure Presented) Bacterial acyl-homoserlne lactones upregulated an uncharacterlzed gene cluster (bta) In Burkholderla thallandensls E264 to produce an uncharacterlzed polar antibiotic. The antibiotic Is Identified as a mixture of four bactobollns. Annotation of the bta cluster allows us to propose a blosynthetlc scheme for bactobolln and reveals unusual enzymatic reactions for further study.

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JO - Organic Letters

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ER -

Quorum-sensing-regulated bActobolin Production by burkholderia thailandensis E264

Abstract

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