TY - GEN
T1 - Quantitative simultaneous In-111/ Tc-99m planar imaging of the foot
AU - Zhu, X.
AU - Park, M. A.
AU - Moore, S. C.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2006
Y1 - 2006
N2 - Tc-99m and In-111-white blood cell (WBC) imaging are useful for discriminating osteomyelitis from cellulitis of the foot. Accurate diagnosis from sequential studies is challenging because the images are not registered and the Tc-99m/In-111 ratio is assessed subjectively. We developed a simultaneous dual-radionuclide imaging method in which Tc-99m scans are acquired in perfect spatial registration with In-111 WBC images. A foot phantom was made using five tubes containing Tc/In activity ratios from 0.13 to 3.80. The tubes were positioned at a shallow angle in a 5-cm-deep water layer. A single tube was first imaged in list-mode over 18 hours, providing a wide range of Tc/In activity ratios for optimizing triple-energy-window (TEW) parameters for scatter and crosstalk correction of both nuclides. Twelve Poisson noise realizations were generated from very low-noise opposed images of the foot phantom. We measured the bias of Tc/In ratios in regions-of-interest (ROIs) on each tube, along with the uniformity and precision of ROI counts for both nuclides, with (cor) and without (uncor) TEW and geometricmean (GM) attenuation compensation. The average uniformity along the tubes improved for Tc from 13% (uncor) to 5.6% (cor), and for In from 12.8% (uncor) to 4.4% (cor). The average absolute bias of the Tc/In ratio over all tubes was 4.5% (cor) vs. 48.4% (uncor), with comparable precision. Simultaneous Tc/In acquisition with TEW+GM corrections provides a useful approach for foot imaging.
AB - Tc-99m and In-111-white blood cell (WBC) imaging are useful for discriminating osteomyelitis from cellulitis of the foot. Accurate diagnosis from sequential studies is challenging because the images are not registered and the Tc-99m/In-111 ratio is assessed subjectively. We developed a simultaneous dual-radionuclide imaging method in which Tc-99m scans are acquired in perfect spatial registration with In-111 WBC images. A foot phantom was made using five tubes containing Tc/In activity ratios from 0.13 to 3.80. The tubes were positioned at a shallow angle in a 5-cm-deep water layer. A single tube was first imaged in list-mode over 18 hours, providing a wide range of Tc/In activity ratios for optimizing triple-energy-window (TEW) parameters for scatter and crosstalk correction of both nuclides. Twelve Poisson noise realizations were generated from very low-noise opposed images of the foot phantom. We measured the bias of Tc/In ratios in regions-of-interest (ROIs) on each tube, along with the uniformity and precision of ROI counts for both nuclides, with (cor) and without (uncor) TEW and geometricmean (GM) attenuation compensation. The average uniformity along the tubes improved for Tc from 13% (uncor) to 5.6% (cor), and for In from 12.8% (uncor) to 4.4% (cor). The average absolute bias of the Tc/In ratio over all tubes was 4.5% (cor) vs. 48.4% (uncor), with comparable precision. Simultaneous Tc/In acquisition with TEW+GM corrections provides a useful approach for foot imaging.
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U2 - 10.1109/NSSMIC.2006.356434
DO - 10.1109/NSSMIC.2006.356434
M3 - Conference contribution
AN - SCOPUS:38549132916
SN - 1424405610
SN - 9781424405619
T3 - IEEE Nuclear Science Symposium Conference Record
SP - 2684
EP - 2687
BT - 2006 IEEE Nuclear Science Symposium - Conference Record
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD
Y2 - 29 October 2006 through 4 November 2006
ER -