Quantitative metabolomic and lipidomic profiling reveals aberrant amino acid metabolism in type 2 diabetes

Prabhjit Kaur; Nasser Rizk; Sereen Ibrahim; Yue Luo; Noura Younes; Brian Perry; Kevin Dennis; Mahmoud Zirie; George Luta; Amrita K. Cheema

doi:10.1039/c2mb25384d

Quantitative metabolomic and lipidomic profiling reveals aberrant amino acid metabolism in type 2 diabetes

Prabhjit Kaur, Nasser Rizk, Sereen Ibrahim, Yue Luo, Noura Younes, Brian Perry, Kevin Dennis, Mahmoud Zirie, George Luta, Amrita K. Cheema

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Type 2 diabetes (T2DM) is a multi-factorial disease with a complex pathogenic mechanism; however a complete understanding of precise biochemical alterations accompanying the onset and progression of T2DM is lacking. Using a combination of untargeted and targeted metabolomic profiling approach we were able to delineate significantly altered metabolites in the diabetic (T2DM) group. Our results indicate significant perturbations in amino acid metabolism, TCA cycle and glycerol-phospholipid metabolism possibly impacting the overall glucose homeostasis in T2DM. A systems approach offers promise towards identification of clinically relevant markers of T2DM and novel molecular targets to foster drug discovery for effective therapeutic development for diabetes.

Original language	English (US)
Pages (from-to)	307-317
Number of pages	11
Journal	Molecular BioSystems
Volume	9
Issue number	2
DOIs	https://doi.org/10.1039/c2mb25384d
State	Published - Feb 2013
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Molecular Biology

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abstract = "Type 2 diabetes (T2DM) is a multi-factorial disease with a complex pathogenic mechanism; however a complete understanding of precise biochemical alterations accompanying the onset and progression of T2DM is lacking. Using a combination of untargeted and targeted metabolomic profiling approach we were able to delineate significantly altered metabolites in the diabetic (T2DM) group. Our results indicate significant perturbations in amino acid metabolism, TCA cycle and glycerol-phospholipid metabolism possibly impacting the overall glucose homeostasis in T2DM. A systems approach offers promise towards identification of clinically relevant markers of T2DM and novel molecular targets to foster drug discovery for effective therapeutic development for diabetes.",

author = "Prabhjit Kaur and Nasser Rizk and Sereen Ibrahim and Yue Luo and Noura Younes and Brian Perry and Kevin Dennis and Mahmoud Zirie and George Luta and Cheema, {Amrita K.}",

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T1 - Quantitative metabolomic and lipidomic profiling reveals aberrant amino acid metabolism in type 2 diabetes

AU - Kaur, Prabhjit

AU - Rizk, Nasser

AU - Ibrahim, Sereen

AU - Luo, Yue

AU - Younes, Noura

AU - Perry, Brian

AU - Dennis, Kevin

AU - Zirie, Mahmoud

AU - Luta, George

AU - Cheema, Amrita K.

PY - 2013/2

Y1 - 2013/2

N2 - Type 2 diabetes (T2DM) is a multi-factorial disease with a complex pathogenic mechanism; however a complete understanding of precise biochemical alterations accompanying the onset and progression of T2DM is lacking. Using a combination of untargeted and targeted metabolomic profiling approach we were able to delineate significantly altered metabolites in the diabetic (T2DM) group. Our results indicate significant perturbations in amino acid metabolism, TCA cycle and glycerol-phospholipid metabolism possibly impacting the overall glucose homeostasis in T2DM. A systems approach offers promise towards identification of clinically relevant markers of T2DM and novel molecular targets to foster drug discovery for effective therapeutic development for diabetes.

AB - Type 2 diabetes (T2DM) is a multi-factorial disease with a complex pathogenic mechanism; however a complete understanding of precise biochemical alterations accompanying the onset and progression of T2DM is lacking. Using a combination of untargeted and targeted metabolomic profiling approach we were able to delineate significantly altered metabolites in the diabetic (T2DM) group. Our results indicate significant perturbations in amino acid metabolism, TCA cycle and glycerol-phospholipid metabolism possibly impacting the overall glucose homeostasis in T2DM. A systems approach offers promise towards identification of clinically relevant markers of T2DM and novel molecular targets to foster drug discovery for effective therapeutic development for diabetes.

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Quantitative metabolomic and lipidomic profiling reveals aberrant amino acid metabolism in type 2 diabetes

Abstract

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