Quantification and visualization of oxygen partial pressure in vivo by19f NMR imaging of perfluorocarbons

M. E. Bellemann; J. Brückner; P. Peschke; G. Brix; R. P. Mason

doi:10.1515/bmte.2002.47.s1a.451

Quantification and visualization of oxygen partial pressure in vivo by¹⁹f NMR imaging of perfluorocarbons

M. E. Bellemann, J. Brückner, P. Peschke, G. Brix, R. P. Mason

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Due to the high solubility ofmolecular oxygen in perfluorocarbons (PFC), this class offluorinated compounds hos gained wide-spread interestfor its biomedical application äs temporary blood substitutes and as radiosensitizers. Since the observation that the NMR spin-lattice relaxation times (T₁) of some ¹⁹F PFC resonances are sensitive to oxygen tension (pOJ, this paramagnetic effect hos been used to non-invasively probe pO2 in vivo. In this study, combined ¹⁹F/HNMR Image data ofCopenhagen rats öfter PFC application were evaluated with the Software package MATLAB. The analysis of the ¹⁹F NMR data resulted in Image matrices with calculated Tt values in each pixel By using a calibration curve, the corresponding pO₂values were computed. Color overlays of pO₂contour lines on Trweighted ¹H Images show a good anatomical-foinctional correspondence.

Original language	English (US)
Pages (from-to)	451-454
Number of pages	4
Journal	Biomedizinische Technik
Volume	47
Issue number	s1a
DOIs	https://doi.org/10.1515/bmte.2002.47.s1a.451
State	Published - 2002

Keywords

Nuclear magnetic resonance (NMR)
Oxygen partial pressure (pO)
Tissue oxygenation

ASJC Scopus subject areas

Biomedical Engineering

Access to Document

10.1515/bmte.2002.47.s1a.451

Cite this

@article{04d698729066491a9e307a4bec52a7f2,

title = "Quantification and visualization of oxygen partial pressure in vivo by19f NMR imaging of perfluorocarbons",

abstract = "Due to the high solubility ofmolecular oxygen in perfluorocarbons (PFC), this class offluorinated compounds hos gained wide-spread interestfor its biomedical application {\"a}s temporary blood substitutes and as radiosensitizers. Since the observation that the NMR spin-lattice relaxation times (T1) of some 19F PFC resonances are sensitive to oxygen tension (pOJ, this paramagnetic effect hos been used to non-invasively probe pO2 in vivo. In this study, combined 19F/HNMR Image data ofCopenhagen rats {\"o}fter PFC application were evaluated with the Software package MATLAB. The analysis of the 19F NMR data resulted in Image matrices with calculated Tt values in each pixel By using a calibration curve, the corresponding pO2values were computed. Color overlays of pO2contour lines on Trweighted 1H Images show a good anatomical-foinctional correspondence.",

keywords = "Nuclear magnetic resonance (NMR), Oxygen partial pressure (pO), Tissue oxygenation",

author = "Bellemann, {M. E.} and J. Br{\"u}ckner and P. Peschke and G. Brix and Mason, {R. P.}",

year = "2002",

doi = "10.1515/bmte.2002.47.s1a.451",

language = "English (US)",

volume = "47",

pages = "451--454",

journal = "Biomedizinische Technik",

issn = "0013-5585",

publisher = "Walter de Gruyter GmbH & Co. KG",

number = "s1a",

}

TY - JOUR

T1 - Quantification and visualization of oxygen partial pressure in vivo by19f NMR imaging of perfluorocarbons

AU - Bellemann, M. E.

AU - Brückner, J.

AU - Peschke, P.

AU - Brix, G.

AU - Mason, R. P.

PY - 2002

Y1 - 2002

N2 - Due to the high solubility ofmolecular oxygen in perfluorocarbons (PFC), this class offluorinated compounds hos gained wide-spread interestfor its biomedical application äs temporary blood substitutes and as radiosensitizers. Since the observation that the NMR spin-lattice relaxation times (T1) of some 19F PFC resonances are sensitive to oxygen tension (pOJ, this paramagnetic effect hos been used to non-invasively probe pO2 in vivo. In this study, combined 19F/HNMR Image data ofCopenhagen rats öfter PFC application were evaluated with the Software package MATLAB. The analysis of the 19F NMR data resulted in Image matrices with calculated Tt values in each pixel By using a calibration curve, the corresponding pO2values were computed. Color overlays of pO2contour lines on Trweighted 1H Images show a good anatomical-foinctional correspondence.

AB - Due to the high solubility ofmolecular oxygen in perfluorocarbons (PFC), this class offluorinated compounds hos gained wide-spread interestfor its biomedical application äs temporary blood substitutes and as radiosensitizers. Since the observation that the NMR spin-lattice relaxation times (T1) of some 19F PFC resonances are sensitive to oxygen tension (pOJ, this paramagnetic effect hos been used to non-invasively probe pO2 in vivo. In this study, combined 19F/HNMR Image data ofCopenhagen rats öfter PFC application were evaluated with the Software package MATLAB. The analysis of the 19F NMR data resulted in Image matrices with calculated Tt values in each pixel By using a calibration curve, the corresponding pO2values were computed. Color overlays of pO2contour lines on Trweighted 1H Images show a good anatomical-foinctional correspondence.

KW - Nuclear magnetic resonance (NMR)

KW - Oxygen partial pressure (pO)

KW - Tissue oxygenation

UR - http://www.scopus.com/inward/record.url?scp=2242486320&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2242486320&partnerID=8YFLogxK

U2 - 10.1515/bmte.2002.47.s1a.451

DO - 10.1515/bmte.2002.47.s1a.451

M3 - Article

C2 - 12451890

AN - SCOPUS:2242486320

SN - 0013-5585

VL - 47

SP - 451

EP - 454

JO - Biomedizinische Technik

JF - Biomedizinische Technik

IS - s1a

ER -