TY - JOUR
T1 - Quality Improvement of Staphylococcus aureus Bacteremia Management and Predictors of Relapse-free Survival
AU - Townsend, Jennifer
AU - Pelletier, Jamie
AU - Peterson, Gail
AU - Matulevicius, Susan
AU - Sreeramoju, Pranavi
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Purpose The purpose of this study is to improve the quality of care and patient outcomes for Staphylococcus aureus bacteremia. Methods A quasi-experimental pre- and postintervention study design was used to compare process and clinical endpoints before and after a quality-improvement initiative. All inpatients >18 years of age with a positive blood culture for S. aureus during the specified pre- and postintervention period with clinical information available in the electronic medical record were included. An institutional protocol for the care of patients with S. aureus bacteremia was developed, formalized, and distributed to providers using a pocket card, an electronic order set, and targeted lectures over a 9-month period. Results There were 167 episodes of S. aureus bacteremia (160 patients) identified in the preintervention period, and 127 episodes (123 patients) in the postintervention period. Guideline adherence improved in the postintervention period for usage of transesophageal echocardiogram (43.9% vs 20.2%, P <.01) and adequate duration of intravenous therapy (71% vs 60%, P =.05). In a multivariate Cox proportional hazard model, the variables associated with increased relapse-free survival were postintervention period (hazard ratio [HR] 0.48; confidence interval [CI], 0.24-0.95; P.035) and appropriate source control (HR 0.53; CI, 0.24-0.92; P.027). Regardless of intervention, presence of cancer was associated with an increased risk of relapse or mortality at 90 days (HR 2.88; P <.0001; CI, 1.35-5.01). Conclusion A bundled educational intervention to promote adherence to published guidelines for the treatment of S. aureus bacteremia resulted in a significant improvement in provider adherence to guidelines as well as increased 90-day relapse-free survival.
AB - Purpose The purpose of this study is to improve the quality of care and patient outcomes for Staphylococcus aureus bacteremia. Methods A quasi-experimental pre- and postintervention study design was used to compare process and clinical endpoints before and after a quality-improvement initiative. All inpatients >18 years of age with a positive blood culture for S. aureus during the specified pre- and postintervention period with clinical information available in the electronic medical record were included. An institutional protocol for the care of patients with S. aureus bacteremia was developed, formalized, and distributed to providers using a pocket card, an electronic order set, and targeted lectures over a 9-month period. Results There were 167 episodes of S. aureus bacteremia (160 patients) identified in the preintervention period, and 127 episodes (123 patients) in the postintervention period. Guideline adherence improved in the postintervention period for usage of transesophageal echocardiogram (43.9% vs 20.2%, P <.01) and adequate duration of intravenous therapy (71% vs 60%, P =.05). In a multivariate Cox proportional hazard model, the variables associated with increased relapse-free survival were postintervention period (hazard ratio [HR] 0.48; confidence interval [CI], 0.24-0.95; P.035) and appropriate source control (HR 0.53; CI, 0.24-0.92; P.027). Regardless of intervention, presence of cancer was associated with an increased risk of relapse or mortality at 90 days (HR 2.88; P <.0001; CI, 1.35-5.01). Conclusion A bundled educational intervention to promote adherence to published guidelines for the treatment of S. aureus bacteremia resulted in a significant improvement in provider adherence to guidelines as well as increased 90-day relapse-free survival.
KW - Bacteremia/drug therapy
KW - Methicillin resistance
KW - Quality control
KW - Staphylococcal infections/drug therapy
KW - Staphylococcal infections/microbiology
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U2 - 10.1016/j.amjmed.2015.09.016
DO - 10.1016/j.amjmed.2015.09.016
M3 - Article
C2 - 26519616
AN - SCOPUS:84973408911
SN - 0002-9343
VL - 129
SP - 195
EP - 203
JO - American Journal of Medicine
JF - American Journal of Medicine
IS - 2
ER -