Pulmonary manifestations of large, medium, and variable vessel vasculitis

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


The hallmark of vasculitis is autoimmune inflammation of blood vessels and surrounding tissues, resulting in an array of constitutional symptoms and organ damage. The lung is commonly targeted in the more familiar ANCA-associated small vessel vasculitidies, but large and medium vessel vasculitides, including Takayasu arteritis, giant cell arteritis, polyarteritis nodosa, Behcet's disease, and necrotizing sarcoid granulomatosis, may also feature prominent pulmonary involvement. Pulmonary manifestations of these conditions include pulmonary arterial aneurysms, pulmonary hypertension, diffuse alveolar hemorrhage, pulmonary nodules, and parenchymal infiltrates. An understanding of the diverse manifestations of vasculitis and a high index of clinical suspicion are essential to avoid delays in disease recognition that may result in permanent or life threatening morbidity. In this review, we outline the general clinical manifestations, pulmonary manifestations, diagnostic workup, imaging findings, and treatment of medium, large, and variable vessel vasculitides.

Original languageEnglish (US)
Pages (from-to)182-191
Number of pages10
JournalRespiratory Medicine
StatePublished - Dec 2018


  • Aneurysm
  • Arteritis
  • Vasculitis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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