Pseudomelanosis duodeni in an adolescent male: Case report and review of the literature

Pueblitz Siegfried, Robert H. Squires, Charles F. Timmons

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Pseudomelanosis duodeni is rarely seen in children. It manifests endoscopically as peppery speckles in the duodenal mucosa. This pigment corresponds principally to accumulation of ferrous sulfide in macrophages within the lamina propria. We report the case of a 16-year-old boy with ectodermal dysplasia who underwent renal transplantation for vesicoureteral reflux and later developed epigastric pain. Endoscopic and pathologic findings in the duodenal mucosa were typical of pseudomelanosis duodeni. A review of the literature reveals shared clinical features among reported adult and pediatric cases, including chronic renal failure, use of antihypertensive medication and oral iron supplementation, and/or presence of gastric hemorrhage.

Original languageEnglish (US)
Pages (from-to)115-123
Number of pages9
JournalPediatric Pathology and Laboratory Medicine
Issue number1
StatePublished - Feb 20 1997


  • duodenum
  • electron microscopy
  • endoscopy
  • melanosis
  • pseudomelanosis
  • renal failure

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine


Dive into the research topics of 'Pseudomelanosis duodeni in an adolescent male: Case report and review of the literature'. Together they form a unique fingerprint.

Cite this