Protein breakdown inhibited by insulin to improve heart culture

Kern Wildenthal

doi:10.1038/239101a0

Protein breakdown inhibited by insulin to improve heart culture

Kern Wildenthal

Internal Medicine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

EVEN in the best systems currently available for maintaining isolated hearts in vitro, progressive deterioration and death of the organs occur. To provide a convenient means for studying the factors that control long-term survival and function of isolated myocardium a method has recently been developed for maintaining spontaneously-beating hearts from late foetal mice in organ culture¹. The technique, which was developed from the general methods for culturing other organs used by Fell and her colleagues², enables function to be preserved for several days or weeks before death finally occurs^1,3,4.

Original language	English (US)
Pages (from-to)	101-102
Number of pages	2
Journal	Nature
Volume	239
Issue number	5367
DOIs	https://doi.org/10.1038/239101a0
State	Published - Dec 1 1972

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abstract = "EVEN in the best systems currently available for maintaining isolated hearts in vitro, progressive deterioration and death of the organs occur. To provide a convenient means for studying the factors that control long-term survival and function of isolated myocardium a method has recently been developed for maintaining spontaneously-beating hearts from late foetal mice in organ culture1. The technique, which was developed from the general methods for culturing other organs used by Fell and her colleagues2, enables function to be preserved for several days or weeks before death finally occurs1,3,4.",

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AB - EVEN in the best systems currently available for maintaining isolated hearts in vitro, progressive deterioration and death of the organs occur. To provide a convenient means for studying the factors that control long-term survival and function of isolated myocardium a method has recently been developed for maintaining spontaneously-beating hearts from late foetal mice in organ culture1. The technique, which was developed from the general methods for culturing other organs used by Fell and her colleagues2, enables function to be preserved for several days or weeks before death finally occurs1,3,4.

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Protein breakdown inhibited by insulin to improve heart culture

Abstract

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