Abstract
Background: Aged hearts are particularly vulnerable to reperfusion injury. We recently showed that single-dose del Nido cardioplegia was superior to 'standard' multi-dose 4:1 blood cardioplegia in aged rat hearts. This study seeks to determine if multi-dose del Nido cardioplegia offers additional benefits over single-dose del Nido cardioplegia. Methods: Functional recovery after 60 min of cardioplegic arrest was assessed in isolated, working, senescent rat hearts. Single-dose del Nido cardioplegia (n=14) was compared to multi-dose del Nido cardioplegia (n=12) delivered every 20 min. Results: Troponin release during reperfusion was similar in the single (0.263±0.056 ng/ml) and multi-dose groups (0.261±0.055 ng/ml). Although functional recovery was similar early after reperfusion (stroke work 91±6 ml∗mmHg∗g-1 vs. 91±8 ml∗mmHg∗g-1 for single- vs. multi-dose), it declined over time in the multi-dose group (71±9 vs. 43±9 ml∗mmHg∗g-1 at 60 min, p=0.0175) Conclusions: In aged rat hearts, a single-dose del Nido cardioplegia strategy results in superior functional recovery compared to a multi-dose del Nido cardioplegia strategy.
Original language | English (US) |
---|---|
Pages (from-to) | 135-142 |
Number of pages | 8 |
Journal | Perfusion (United Kingdom) |
Volume | 31 |
Issue number | 2 |
DOIs | |
State | Published - Mar 1 2016 |
Keywords
- aged heart
- del Nido cardioplegia
- ischemia-reperfusion injury
- working heart
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Safety Research
- Cardiology and Cardiovascular Medicine
- Advanced and Specialized Nursing