@article{11a222a1baf84850983fc494018638a6,
title = "Prostate carcinogenesis: inflammatory storms",
abstract = "Prostate cancer is a major cause of cancer morbidity and mortality. Intra-prostatic inflammation is a risk factor for prostate carcinogenesis, with diet, chemical injury and an altered microbiome being causally implicated. Intra-prostatic inflammatory cell recruitment and expansion can ultimately promote DNA double-strand breaks and androgen receptor activation in prostate epithelial cells. The activation of the senescence-associated secretory phenotype fuels further {\textquoteleft}inflammatory storms{\textquoteright}, with free radicals leading to further DNA damage. This drives the overexpression of DNA repair and tumour suppressor genes, rendering these genes susceptible to mutagenic insults, with carcinogenesis accelerated by germline DNA repair gene defects. We provide updates on recent advances in elucidating prostate carcinogenesis and explore novel therapeutic and prevention strategies harnessing these discoveries.",
author = "{de Bono}, {Johann S.} and Christina Guo and Bora Gurel and {De Marzo}, {Angelo M.} and Sfanos, {Karen S.} and Mani, {Ram S.} and Jes{\'u}s Gil and Drake, {Charles G.} and Andrea Alimonti",
note = "Funding Information: J.S.d.B. acknowledges funding from Movember, Prostate Cancer UK, the Prostate Cancer Foundation, Cancer Research UK and the Medical Research Council. J.S.d.B. is a National Institutes of Health Research (NIHR) Senior Investigator. The views expressed in this article are those of the author(s) and not necessarily those of the National Health Service, the NIHR or the Department of Health. K.S.S. acknowledges support from the Prostate Cancer Foundation. R.S.M. acknowledges funding from an NIH/NCI R01 grant (R01CA245294), the CPRIT Individual Investigator Research Award (RP190454) and an Impact Award from the U.S. Department of Defense Prostate Cancer Research Program (W81XWH-17-1-0675). C.G.D. was supported by the Prostate Cancer Foundation, U.S. Department of Defense grant W81XWH-13-1-0369 and the Patrick C. Walsh Fund. A.A. was supported by European Research Council Consolidator grant 683136, Swiss Cancer League grant KFS4267-08-2017, SNSF grant 310030_176045, Prostate Cancer Foundation grant 19CHAL08 and a Fondazione Italiana per la ricerca sul Cancro (AIRC) Investigator Grant (22030). Publisher Copyright: {\textcopyright} 2020, Springer Nature Limited.",
year = "2020",
month = aug,
day = "1",
doi = "10.1038/s41568-020-0267-9",
language = "English (US)",
volume = "20",
pages = "455--469",
journal = "Nature Reviews Cancer",
issn = "1474-175X",
publisher = "Nature Publishing Group",
number = "8",
}