Prostate cancer detection using crawling wave sonoelastography

Benjamin Castaneda, Liwei An, Shuang Wu, Laurie L. Baxter, Jorge L. Yao, Jean V. Joseph, Kenneth Hoyt, John Strang, Deborah J. Rubens, Kevin J. Parker

Research output: Chapter in Book/Report/Conference proceedingConference contribution

30 Scopus citations


Crawling wave (CrW) sonoelastography is an elasticity imaging technique capable of estimating the localized shear wave speed in tissue and, therefore, can provide a quantitative estimation of the Young's modulus for a given vibration frequency. In this paper, this technique is used to detect cancer in excised human prostates and to provide quantitative estimations of the viscoelastic properties of cancerous and normal tissues. Image processing techniques are introduced to compensate for attenuation and reflection artifacts of the CrW images. Preliminary results were obtained with fifteen prostate glands after radical prostatectomy. The glands were vibrated at 100, 120 and 140Hz. At each frequency, three cross-sections of the gland (apex, mid-gland and base) were imaged using CrW Sonoelastography and compared to corresponding histological slices. Results showed good spatial correspondence with histology and an 80% accuracy in cancer detection. In addition, shear velocities for cancerous and normal tissues were estimated as 4.75±0.97 m/s and 3.26±0.87 m/s, respectively.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2009
Subtitle of host publicationUltrasonic Imaging and Signal Processing
StatePublished - 2009
EventMedical Imaging 2009: Ultrasonic Imaging and Signal Processing - Lake Buena Vista, FL, United States
Duration: Feb 8 2009Feb 9 2009

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMedical Imaging 2009: Ultrasonic Imaging and Signal Processing
Country/TerritoryUnited States
CityLake Buena Vista, FL


  • Crawling wave sonoelastography
  • Elasticity imaging
  • Image processing
  • Prostate cancer detection
  • Tissue characterization

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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