TY - JOUR
T1 - Prospects for prevention and treatment of cancer with selective PPARγ modulators (SPARMs)
AU - Sporn, Michael B.
AU - Suh, Nanjoo
AU - Mangelsdorf, David J.
N1 - Funding Information:
This work was supported by the National Foundation for Cancer Research, the Oliver and Jennie Donaldson Trust, NIH Grant R01 CA78814, the Dept of Defense (DAMD17-99-1-9168 and DAMD17-98-1-8604), and the Howard Hughes Medical Institute. We thank Millard Lambert for Fig. 2 , and DominicKlyve for expert assistance in the preparation of this review. M.B.S. is the OscarM.Cohn Professor.
PY - 2001
Y1 - 2001
N2 - Peroxisome proliferator-activated receptor γ(PPARγ), a nuclear receptor and transcription factor that regulates the expression of many genes relevant to carcinogenesis, is now an important target for development of new drugs for the prevention and treatment of cancer. Deficient expression of PPARγ can be a significant risk factor for carcinogenesis, although in some cases overexpression enhances carcinogenesis. Ligands for PPARγ suppress breast carcinogenesis in experimental models and induce differentiation of human liposarcoma cells. By analogy to the selective estrogen receptor modulator (SERM) concept, it is suggested that selective PPARγ modulators (SPARMs), designed to have desired effects on specific genes and target tissues without undesirable effects on others, will be clinically important in the future for chemoprevention and chemotherapy of cancer.
AB - Peroxisome proliferator-activated receptor γ(PPARγ), a nuclear receptor and transcription factor that regulates the expression of many genes relevant to carcinogenesis, is now an important target for development of new drugs for the prevention and treatment of cancer. Deficient expression of PPARγ can be a significant risk factor for carcinogenesis, although in some cases overexpression enhances carcinogenesis. Ligands for PPARγ suppress breast carcinogenesis in experimental models and induce differentiation of human liposarcoma cells. By analogy to the selective estrogen receptor modulator (SERM) concept, it is suggested that selective PPARγ modulators (SPARMs), designed to have desired effects on specific genes and target tissues without undesirable effects on others, will be clinically important in the future for chemoprevention and chemotherapy of cancer.
UR - http://www.scopus.com/inward/record.url?scp=0034847431&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034847431&partnerID=8YFLogxK
U2 - 10.1016/S1471-4914(01)02100-1
DO - 10.1016/S1471-4914(01)02100-1
M3 - Review article
C2 - 11530334
AN - SCOPUS:0034847431
SN - 1471-4914
VL - 7
SP - 395
EP - 400
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 9
ER -