Prophylactic Sclerotherapy of Large Esophageal Varices

Bret A. Lashner, Ira M. Hanan, Meir Stampfer, S. W. Hosking, A. G. Johnson, Harry Snady, Paolo Paoluzi, Antonio Pietroiusti, William C. Santangelo, Maria I. Dueno, Boyce L. Estes, Guenter J. Krejs

Research output: Contribution to journalLetterpeer-review

5 Scopus citations


To the Editor: In the article on prophylactic sclerotherapy (March 31 issue),1 it may be true that sclerotherapy had no effect, but Santangelo et al. have not adequately eliminated the possibility that a Type II error accounted for the negative results. We must take exception to the calculations of the authors regarding the power of the study. In the Methods section of their article they state that 74 patients would be required to demonstrate a 50 percent reduction in the bleeding rate with sclerotherapy, assuming that 40 percent of the patients in the control group bled — a statistical power.

Original languageEnglish (US)
Pages (from-to)1015-1017
Number of pages3
JournalNew England Journal of Medicine
Issue number15
StatePublished - Oct 13 1988

ASJC Scopus subject areas

  • Medicine(all)


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