Progressive supranuclear palsy with dementia: Cortical pathology

Eileen H. Bigio, Daniel F. Brown, Charles L. White

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


Patients with progressive supranuclear palsy (PSP) often develop dementia, and cortical pathology has been documented in PSP. However, there are no reports correlating dementia in PSP with cortical pathology. We hypothesized that cases of PSP presenting with cognitive impairment would have more severe cortical tau pathology than those without. We compared 7 cases of PSP presenting with cognitive deficits (group 1) with 4 cases of PSP that did not (group 2). The subcortical tau pathology was almost identical in both groups. The cortical tau pathology was strikingly different in group 1, in which it was on average moderate, compared with group 2, in which it was minimal. The accumulation of cortical neuronoglial tau in PSP cases with dementia suggests that neurofibrillary pathology is central to the cause of dementia in PSP.

Original languageEnglish (US)
Pages (from-to)359-364
Number of pages6
JournalJournal of neuropathology and experimental neurology
Issue number4
StatePublished - Apr 1999


  • Alzheimer disease
  • Cortical
  • Dementia
  • Pathology
  • Progressive
  • Subcortical
  • Supranuclear palsy
  • Tau

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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