TY - JOUR
T1 - Prognostic significance of NADPH quinine oxidoreductase 1 overexpression in head and neck squamous cell carcinoma
AU - Yang, Yang
AU - Tiefeng, Jin
AU - Shuangping, Liu
AU - Liyan, Chen
AU - Lijuan, Lin
AU - Hongxiu, Han
AU - Longshan, Li
AU - Zhenhua, Lin
PY - 2014/7/8
Y1 - 2014/7/8
N2 - Objective: To investigate the significance of NADPH quinine oxidoreductase 1 (NQ01) protein overexpression on prognostic evaluation of head and neck squamous cell carcinoma (HNSCC). Methods: NQ01 protein was detected in 162 of HNSCC, 45 cases of adjacent nontumor tissues and 26 samples of normal head and neck epithelia using EnVision immunohistochemical. Correlation between NQ01 overexpression and patients prognosis was also analyzed. Results: The positive rate and strongly positive rate of NQOl protein were 84. 0% (136/162) and 69. 8% (113/162) in HNSCC, respectively, and both of which were significantly higher than either those in adjacent nontumor tissues and normal head and neck epithelia (both P < 0. 01). NQOl expression was significantly correlated with the clinical stage, pT and chemoradiotherapy of HNSCC (P<0. 01). Kaplan-Meier survival analysis showed that overall survival and disease-free survival rates were significantly higher in HNSCC patients with high level NQOl expression than that those with low level of NQ01 expression (Log-rank = 6. 625, P = 0. 010; Log-rank = 6. 234, P = 0.013). Additional analysis by Cox proportional hazard regression model showed that high level of NQOl expression was an independent hazard predictor for overall survival of patients with HNSCC (Wald = 6. 626, P = 0. 008). Conclusions: NQOl expression level is closely correlated with the progression and prognosis of patients with HNSCC. High level of NQOl expression may be used as an important indicator for patients with poor prognostic HNSCC.
AB - Objective: To investigate the significance of NADPH quinine oxidoreductase 1 (NQ01) protein overexpression on prognostic evaluation of head and neck squamous cell carcinoma (HNSCC). Methods: NQ01 protein was detected in 162 of HNSCC, 45 cases of adjacent nontumor tissues and 26 samples of normal head and neck epithelia using EnVision immunohistochemical. Correlation between NQ01 overexpression and patients prognosis was also analyzed. Results: The positive rate and strongly positive rate of NQOl protein were 84. 0% (136/162) and 69. 8% (113/162) in HNSCC, respectively, and both of which were significantly higher than either those in adjacent nontumor tissues and normal head and neck epithelia (both P < 0. 01). NQOl expression was significantly correlated with the clinical stage, pT and chemoradiotherapy of HNSCC (P<0. 01). Kaplan-Meier survival analysis showed that overall survival and disease-free survival rates were significantly higher in HNSCC patients with high level NQOl expression than that those with low level of NQ01 expression (Log-rank = 6. 625, P = 0. 010; Log-rank = 6. 234, P = 0.013). Additional analysis by Cox proportional hazard regression model showed that high level of NQOl expression was an independent hazard predictor for overall survival of patients with HNSCC (Wald = 6. 626, P = 0. 008). Conclusions: NQOl expression level is closely correlated with the progression and prognosis of patients with HNSCC. High level of NQOl expression may be used as an important indicator for patients with poor prognostic HNSCC.
KW - Disease-free survival
KW - Head and neck neoplasms
KW - Immunohistochemistry
KW - Prognosis
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U2 - 10.3760/cma.j.issn.0529-5807.2014.07.008
DO - 10.3760/cma.j.issn.0529-5807.2014.07.008
M3 - Article
C2 - 25327796
AN - SCOPUS:84905661355
SN - 0529-5807
VL - 43
SP - 463
EP - 467
JO - Chinese Journal of Pathology
JF - Chinese Journal of Pathology
IS - 7
ER -