TY - JOUR
T1 - Prognostic Performance of RECIP 1.0 Based on [18F]PSMA-1007 PET in Prostate Cancer Patients Treated with [177Lu]Lu-PSMA I&T
AU - Hartrampf, Philipp E.
AU - Hüttmann, Thomas
AU - Seitz, Anna Katharina
AU - Kübler, Hubert
AU - Serfling, Sebastian E.
AU - Higuchi, Takahiro
AU - Schlötelburg, Wiebke
AU - Michalski, Kerstin
AU - Gafita, Andrei
AU - Rowe, Steven P.
AU - Pomper, Martin G.
AU - Buck, Andreas K.
AU - Werner, Rudolf A.
N1 - Publisher Copyright:
© 2024 by the Society of Nuclear Medicine andMolecular Imaging.
PY - 2024
Y1 - 2024
N2 - In metastatic castration-resistant prostate cancer (mCRPC) patients treated with prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT), the recently proposed criteria for evaluating response to PSMA PET (RECIP 1.0) based on 68Ga- and 18F-labeled PET agents provided prognostic information in addition to changes in prostate-specific antigen (PSA) levels. Our aim was to evaluate the prognostic performance of this framework for overall survival (OS) in patients undergoing RLT and imaged with [18F]PSMA-1007 PET/CT and compare the prognostic performance with the PSA-based response assessment. Methods: In total, 73 patients with mCRPC who were scanned with [18F]PSMA-1007 PET/CT before and after 2 cycles of RLT were retrospectively analyzed. We calculated the changes in serum PSA levels (DPSA) and quantitative PET parameters for the whole-body tumor burden (SUVmean, SUVmax, PSMA tumor volume, and total lesion PSMA). Men were also classified following the Prostate Cancer Working Group 3 (PCWG3) criteria for DPSA and RECIP 1.0 for PET imaging response. We performed univariable Cox regression analysis, followed by multivariable and Kaplan-Meier analyses. Results: Median OS was 15mo with a median follow-up time of 14mo. Univariable Cox regression analysis provided significant associations with OS for DPSA (per percentage, hazard ratio [HR], 1.004; 95% CI, 1.002-1.007; P , 0.001) and PSMA tumor volume (per unit, HR, 1.003; 95% CI, 1.000-1.005; P 5 0.03). Multivariable Cox regression analysis confirmed DPSA (per percentage, HR, 1.004; 95% CI, 1.001-1.006; P 5 0.006) as an independent prognosticator for OS. Kaplan-Meier analyses provided significant segregation between individuals with versus those without any PSA response (19mo vs. 14mo; HR, 2.00; 95% CI, 0.95-4.18; P 5 0.04). Differentiation between patients with or without progressive disease (PD) was also feasible when applying PSA-based PCWG3 (19mo vs. 9mo for non- PD and PD, respectively; HR, 2.29; 95% CI, 1.03-5.09; P 5 0.01) but slightly failed when applying RECIP 1.0 (P 5 0.08). A combination of both response systems (PCWG3 and RECIP 1.0), however, yielded the best discrimination between individuals without versus those with PD (19mo vs. 8mo; HR, 2.78; 95% CI, 1.32-5.86; P 5 0.002). Conclusion: In patients with mCRPC treated with RLT and imaged with [18F]PSMA-1007, frameworks integrating both the biochemical (PCWG3) and PET-based response (RECIP 1.0) may best assist in identifying subjects prone to disease progression.
AB - In metastatic castration-resistant prostate cancer (mCRPC) patients treated with prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT), the recently proposed criteria for evaluating response to PSMA PET (RECIP 1.0) based on 68Ga- and 18F-labeled PET agents provided prognostic information in addition to changes in prostate-specific antigen (PSA) levels. Our aim was to evaluate the prognostic performance of this framework for overall survival (OS) in patients undergoing RLT and imaged with [18F]PSMA-1007 PET/CT and compare the prognostic performance with the PSA-based response assessment. Methods: In total, 73 patients with mCRPC who were scanned with [18F]PSMA-1007 PET/CT before and after 2 cycles of RLT were retrospectively analyzed. We calculated the changes in serum PSA levels (DPSA) and quantitative PET parameters for the whole-body tumor burden (SUVmean, SUVmax, PSMA tumor volume, and total lesion PSMA). Men were also classified following the Prostate Cancer Working Group 3 (PCWG3) criteria for DPSA and RECIP 1.0 for PET imaging response. We performed univariable Cox regression analysis, followed by multivariable and Kaplan-Meier analyses. Results: Median OS was 15mo with a median follow-up time of 14mo. Univariable Cox regression analysis provided significant associations with OS for DPSA (per percentage, hazard ratio [HR], 1.004; 95% CI, 1.002-1.007; P , 0.001) and PSMA tumor volume (per unit, HR, 1.003; 95% CI, 1.000-1.005; P 5 0.03). Multivariable Cox regression analysis confirmed DPSA (per percentage, HR, 1.004; 95% CI, 1.001-1.006; P 5 0.006) as an independent prognosticator for OS. Kaplan-Meier analyses provided significant segregation between individuals with versus those without any PSA response (19mo vs. 14mo; HR, 2.00; 95% CI, 0.95-4.18; P 5 0.04). Differentiation between patients with or without progressive disease (PD) was also feasible when applying PSA-based PCWG3 (19mo vs. 9mo for non- PD and PD, respectively; HR, 2.29; 95% CI, 1.03-5.09; P 5 0.01) but slightly failed when applying RECIP 1.0 (P 5 0.08). A combination of both response systems (PCWG3 and RECIP 1.0), however, yielded the best discrimination between individuals without versus those with PD (19mo vs. 8mo; HR, 2.78; 95% CI, 1.32-5.86; P 5 0.002). Conclusion: In patients with mCRPC treated with RLT and imaged with [18F]PSMA-1007, frameworks integrating both the biochemical (PCWG3) and PET-based response (RECIP 1.0) may best assist in identifying subjects prone to disease progression.
KW - PCWG3
KW - PET/CT
KW - PSMA
KW - RECIP
KW - [177Lu]Lu- PSMA I&T
KW - [18F]PSMA-1007
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U2 - 10.2967/jnumed.123.266702
DO - 10.2967/jnumed.123.266702
M3 - Article
C2 - 38453363
AN - SCOPUS:85189209486
SN - 0161-5505
VL - 65
SP - 560
EP - 565
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
IS - 4
ER -