Processed vietnamese ginseng: Preliminary results in chemistry and biological activity

Thi Hong Van Le, Seo Young Lee, Tae Ryong Kim, Jae Young Kim, Sung Won Kwon, Ngoc Khoi Nguyen, Jeong Hill Park, Minh Duc Nguyen

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Background: This study was carried out to investigate the effect of the steaming process on chemical constituents, free radical scavenging activity, and antiproliferative effect of Vietnamese ginseng. Methods: Samples of powdered Vietnamese ginseng were steamed at 120C for various times and their extracts were subjected to chemical and biological studies. Results: Upon steaming, contents of polar ginsenosides, such as Rb1, Rc, Rd, Re, and Rg1, were rapidly decreased, whereas less polar ginsenosides such as Rg3, Rg5, Rk1, Rk3, and Rh4 were increased as reported previously. However, ocotillol type saponins, which have no glycosyl moiety at the C-20 position, were relatively stable on steaming. The radical scavenging activity was increased continuously up to 20 h of steaming. Similarly, the antiproliferative activity against A549 lung cancer cells was also increased. Conclusion: It seems that the antiproliferative activity is closely related to the contents of ginsenoside Rg3, Rg5, and Rk1.

Original languageEnglish (US)
Pages (from-to)154-159
Number of pages6
JournalJournal of Ginseng Research
Issue number2
StatePublished - Oct 15 2014


  • Antiproliferation
  • Ginsenoside
  • Panax vietnamensis
  • Steaming
  • Vietnamese ginseng

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Complementary and alternative medicine


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