Probiotics, prebiotics, and the host microbiome: The science of translation

Bryon Petschow, Joël Doré, Patricia Hibberd, Timothy Dinan, Gregor Reid, Martin Blaser, Patrice D. Cani, Fred H. Degnan, Jane Foster, Glenn Gibson, John Hutton, Todd R. Klaenhammer, Ruth Ley, Max Nieuwdorp, Bruno Pot, David Relman, Andrew Serazin, Mary Ellen Sanders

Research output: Contribution to journalArticlepeer-review

89 Scopus citations


Recent advances in our understanding of the community structure and function of the human microbiome have implications for the potential role of probiotics and prebiotics in promoting human health. A group of experts recently met to review the latest advances in microbiota/microbiome research and discuss the implications for development of probiotics and prebiotics, primarily as they relate to effects mediated via the intestine. The goals of the meeting were to share recent advances in research on the microbiota, microbiome, probiotics, and prebiotics, and to discuss these findings in the contexts of regulatory barriers, evolving healthcare environments, and potential effects on a variety of health topics, including the development of obesity and diabetes; the long-term consequences of exposure to antibiotics early in life to the gastrointestinal (GI) microbiota; lactose intolerance; and the relationship between the GI microbiota and the central nervous system, with implications for depression, cognition, satiety, and mental health for people living in developed and developing countries. This report provides an overview of these discussions.

Original languageEnglish (US)
Pages (from-to)1-17
Number of pages17
JournalAnnals of the New York Academy of Sciences
Issue number1
StatePublished - Dec 2013
Externally publishedYes


  • Health disorders
  • Intestinal microbiota
  • Microbiome
  • Prebiotics
  • Probiotics

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • History and Philosophy of Science


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